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Long COVID 1 year after hospitalisation for COVID-19: a prospective bicentric cohort study.
Becker, Christoph; Beck, Katharina; Zumbrunn, Samuel; Memma, Valentina; Herzog, Naemi; Bissmann, Benjamin; Gross, Sebastian; Loretz, Nina; Mueller, Jonas; Amacher, Simon A.; Bohren, Chantal; Schaefert, Rainer; Bassetti, Stefano; Fux, Christoph; Mueller, Beat; Schuetz, Philipp; Hunziker, Sabina.
  • Becker C; Medical Communication and Psychosomatic Medicine, University Hospital Basel, Switzerland
  • Beck K; Emergency Department, University Hospital Basel, Switzerland
  • Zumbrunn S; Medical Communication and Psychosomatic Medicine, University Hospital Basel, Switzerland
  • Memma V; Medical Communication and Psychosomatic Medicine, University Hospital Basel, Switzerland
  • Herzog N; Medical Communication and Psychosomatic Medicine, University Hospital Basel, Switzerland
  • Bissmann B; Medical Communication and Psychosomatic Medicine, University Hospital Basel, Switzerland
  • Gross S; Medical Communication and Psychosomatic Medicine, University Hospital Basel, Switzerland
  • Loretz N; Medical Communication and Psychosomatic Medicine, University Hospital Basel, Switzerland
  • Mueller J; Medical Communication and Psychosomatic Medicine, University Hospital Basel, Switzerland
  • Amacher SA; Medical Communication and Psychosomatic Medicine, University Hospital Basel, Switzerland
  • Bohren C; Medical Communication and Psychosomatic Medicine, University Hospital Basel, Switzerland
  • Schaefert R; Intensive Care Unit, University Hospital Basel, Switzerland
  • Bassetti S; Medical Communication and Psychosomatic Medicine, University Hospital Basel, Switzerland
  • Fux C; Medical Communication and Psychosomatic Medicine, University Hospital Basel, Switzerland
  • Mueller B; Department for Psychosomatic Medicine, University Hospital Basel, Switzerland
  • Schuetz P; Medical Faculty of the University of Basel, Switzerland
  • Hunziker S; Medical Faculty of the University of Basel, Switzerland
Swiss Med Wkly ; 151: w30091, 2021 10 11.
Article in English | MEDLINE | ID: covidwho-1575761
ABSTRACT
AIMS OF THE STUDY There is increasing interest in better understanding of long COVID, a condition characterised by long-term sequelae ­ appearing or persisting after the typical convalescence period ­ of coronavirus disease 2019 (COVID-19). Herein, we describe long-term outcomes regarding residual symptoms and psychological distress in hospitalised patients 1 year after COVID-19.

METHODS:

This prospective cohort study included consecutive adult patients hospitalised for confirmed COVID-19 in two Swiss tertiary-care hospitals between March and June 2020. The primary endpoint was evidence of long COVID 1 year after discharge, defined as ≥1 persisting or new symptom related to COVID-19, from a predefined list of symptoms. Secondary endpoints included psychological distress and symptoms of post-traumatic stress disorder (PTSD).

RESULTS:

Among 90 patients included in the study, 63 (70%) had symptoms of long COVID 1 year after hospitalisation, particularly fatigue (46%), concentration difficulties (31%), shortness of breath (21%) and post-exertion malaise (20%). Three predictors, namely duration of hospitalisation (odds ratio [OR] 1.11, 95% confidence interval [CI] 1.00­1.22; p = 0.041), severity of illness (OR 1.19, 95% CI 1.04­1.37; p = 0.013), and self-perceived overall health status 30 days after hospitalisation (OR 0.97, 95% CI 0.94­1.00; p = 0.027) were associated with long COVID. Regarding secondary endpoints, 16 (18%) experienced psychological distress and 3 (3.3%) patients had symptoms of PTSD.

CONCLUSION:

A high proportion of COVID-19 patients report symptoms of long COVID 1 year after hospitalisation, which negatively affects their quality of life. The most important risk factors were severe initial presentation of COVID-19 with long hospital stays.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Country/Region as subject: Europa Language: English Journal: Swiss Med Wkly Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Smw.2021.w30091

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Country/Region as subject: Europa Language: English Journal: Swiss Med Wkly Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Smw.2021.w30091