Therapeutic prospect of tetrandrine against SARS-CoV-2 based on its pulmonary pharmacology and exposure character
Acta Pharmaceutica Sinica
; 56(7):1769-1777, 2021.
Article
in Chinese
| CAB Abstracts | ID: covidwho-1575862
ABSTRACT
As the main active compound of Stephania tetrandra S. Moore, tetrandrine (TET) has been used to treat silicosis for nearly 50 years. TET has clear therapeutic effect on pulmonary fibrosis and lung cancer. A recent study suggests that TET may inhibit the replication of SARS-CoV-2 by blocking the two-pore channel 2 (TPC2), revealing its potential as a natural medicine to treat COVID-19. To explore the material basis of TET targeting lung efficacy and its potential toxicity, available literatures related to the pharmacological activity on pulmonary, dosage, toxicity and pharmacokinetics of TET are systemically reviewed. The prospect and current problems of TET to be a therapeutic agent for COVID-19 are further investigated on this basis.
Non-food/Non-feed Plant Products [SS200]; Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Pesticides and Drugs; Control [HH405]; pharmacology; alkaloids; medicinal plants; plant extracts; antiviral properties; coronavirus disease 2019; pathogens; lungs; toxicity; dosage; pharmacokinetics; reviews; human diseases; viral diseases; Severe acute respiratory syndrome coronavirus 2; Stephania tetrandra; man; plants; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Stephania; Menispermaceae; Ranunculales; eudicots; angiosperms; Spermatophyta; eukaryotes; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; SARS-CoV-2; drug plants; medicinal herbs; officinal plants; anti-viral properties; viral infections
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2021
Document Type:
Article
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