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Obesity and gynecological cancers: A toxic relationship.
Wichmann, Ignacio A; Cuello, Mauricio A.
  • Wichmann IA; Division of Gynecology and Obstetrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Cuello MA; Department of Obstetrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Int J Gynaecol Obstet ; 155 Suppl 1: 123-134, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1575902
ABSTRACT
Despite the evidence supporting the relevance of obesity and obesity-associated disorders in the development, management, and prognosis of various cancers, obesity rates continue to increase worldwide. Growing evidence supports the involvement of obesity in the development of gynecologic malignancies. This article explores the molecular basis governing the alteration of hallmarks of cancer in the development of obesity-related gynecologic malignancies encompassing cervical, endometrial, and ovarian cancers. We highlight specific examples of how development, management, and prognosis are affected for each cancer, incorporate current knowledge on complementary approaches including lifestyle interventions to improve patient outcomes, and highlight how new technologies are helping us better understand the biology underlying this neglected pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ovarian Neoplasms / Uterine Cervical Neoplasms / Endometrial Neoplasms / Genital Neoplasms, Female Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans Language: English Journal: Int J Gynaecol Obstet Year: 2021 Document Type: Article Affiliation country: Ijgo.13870

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ovarian Neoplasms / Uterine Cervical Neoplasms / Endometrial Neoplasms / Genital Neoplasms, Female Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans Language: English Journal: Int J Gynaecol Obstet Year: 2021 Document Type: Article Affiliation country: Ijgo.13870