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Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex.
Gruszecka, Agnieszka; Waskow, Monika; Malkiewicz, Marta A; Neary, J Patrick; Singh, Jyotpal; Teckchandani, Taylor; Kratzig, Gregory P; Wszedybyl-Winklewska, Magdalena; Frydrychowski, Andrzej F; Ruminski, Jacek; Glowacka, Natalia; Lass, Piotr; Winklewski, Pawel J; Gruszecki, Marcin.
  • Gruszecka A; Department of Radiology Informatics and Statistics, Medical University of Gdansk, Tuwima Str. 15, 80-210, Gdansk, Poland.
  • Waskow M; Institute of Health Sciences, Pomeranian University of Slupsk, Slupsk, Poland.
  • Malkiewicz MA; Department of Human Physiology, Applied Cognitive Neuroscience Lab, Medical University of Gdansk, Gdansk, Poland.
  • Neary JP; Department of Psychiatry, Medical University of Gdansk, Gdansk, Poland.
  • Singh J; Faculty of Kinesiology and Health Studies, University of Regina, Regina, Canada.
  • Teckchandani T; Faculty of Kinesiology and Health Studies, University of Regina, Regina, Canada.
  • Kratzig GP; Faculty of Kinesiology and Health Studies, University of Regina, Regina, Canada.
  • Wszedybyl-Winklewska M; Department of Psychology, University of Regina, Regina, SK, Canada.
  • Frydrychowski AF; Department of Human Physiology, Medical University of Gdansk, Gdansk, Poland.
  • Ruminski J; NIRTI SA, Wroclaw, Poland.
  • Glowacka N; Department of Biomedical Engineering, Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology, Gdansk, Poland.
  • Lass P; Department of Biomedical Engineering, Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology, Gdansk, Poland.
  • Winklewski PJ; Department of Nuclear Medicine, Medical University of Gdansk, Gdansk, Poland.
  • Gruszecki M; Department of Human Physiology, Medical University of Gdansk, Gdansk, Poland.
Biol Res ; 54(1): 39, 2021 Dec 14.
Article in English | MEDLINE | ID: covidwho-1577124
ABSTRACT

BACKGROUND:

The aim of the study was to investigate the effect of mild cerebral hypoxia on haemoglobin oxygenation (HbO2), cerebrospinal fluid dynamics and cardiovascular physiology. To achieve this goal, four signals were recorded simultaneously blood pressure, heart rate / electrocardiogram, HbO2 from right hemisphere and changes of subarachnoid space (SAS) width from left hemisphere. Signals were registered from 30 healthy, young participants (2 females and 28 males, body mass index = 24.5 ± 2.3 kg/m2, age 30.8 ± 13.4 years).

RESULTS:

We analysed the recorded signals using wavelet transform and phase coherence. We demonstrated for the first time that in healthy subjects exposed to mild poikilokapnic hypoxia there were increases in very low frequency HbO2 oscillations (< 0.052 Hz) in prefrontal cortex. Additionally, SAS fluctuation diminished in the whole frequency range which could be explained by brain oedema.

CONCLUSIONS:

Consequently the study provides insight into mechanisms governing brain response to a mild hypoxic challenge. Our study supports the notion that HbO2 and SAS width monitoring might be beneficial for patients with acute lung disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cerebrovascular Circulation / Lung Diseases Limits: Adolescent / Adult / Female / Humans / Male / Young adult Language: English Journal: Biol Res Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: S40659-021-00362-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cerebrovascular Circulation / Lung Diseases Limits: Adolescent / Adult / Female / Humans / Male / Young adult Language: English Journal: Biol Res Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: S40659-021-00362-2