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Evaluating the role of chemokines and chemokine receptors involved in coronavirus infection.
Olivarria, Gema; Lane, Thomas E.
  • Olivarria G; Department of Neurobiology & Behavior, School of Biological Sciences, University of California, Irvine USA.
  • Lane TE; Department of Neurobiology & Behavior, School of Biological Sciences, University of California, Irvine USA.
Expert Rev Clin Immunol ; 18(1): 57-66, 2022 01.
Article in English | MEDLINE | ID: covidwho-1577592
ABSTRACT

INTRODUCTION:

Coronaviruses are a large family of positive-stranded nonsegmented RNA viruses with genomes of 26-32 kilobases in length. Human coronaviruses are commonly associated with mild respiratory illness; however, the past three decades have seen the emergence of severe acute respiratory coronavirus (SARS-CoV), middle eastern respiratory coronavirus (MERS-CoV), and SARS-CoV-2 which is the etiologic agent for COVID-19. Severe forms of COVID-19 include acute respiratory distress syndrome (ARDS) associated with cytokine release syndrome that can culminate in multiorgan failure and death. Among the proinflammatory factors associated with severe COVID-19 are the chemokines CCL2, CCL3, CXCL8, and CXCL10. Infection of susceptible mice with murine coronaviruses, such as mouse hepatitis virus (MHV), elicits a similar chemokine response profile as observed in COVID-19 patients and these in vivo models have been informative and show that targeting chemokines reduces the severity of inflammation in target organs. AREAS COVERED PubMed was used using keywords Chemokines and coronaviruses; Chemokines and mouse hepatitis virus; Chemokines and COVID-19. Clinicaltrials.gov was used using keywords COVID-19 and chemokines; COVID-19 and cytokines; COVID-19 and neutrophil. EXPERT OPINION Chemokines and chemokine receptors are clinically relevant therapeutic targets for reducing coronavirus-induced inflammation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Chemokine / COVID-19 Type of study: Etiology study / Experimental Studies / Prognostic study / Reviews Limits: Animals / Humans Language: English Journal: Expert Rev Clin Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Chemokine / COVID-19 Type of study: Etiology study / Experimental Studies / Prognostic study / Reviews Limits: Animals / Humans Language: English Journal: Expert Rev Clin Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article