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A Propensity-Matched Analysis of COVID-19 in Kidney Transplant Recipients Compared With Non-Kidney Transplant Patients: A Single-Center Report From India.
Kute, Vivek B; Meshram, Hari Shankar; Chauhan, Sanshriti; Patel, Himanshu; Banerjee, Subho; Desai, Sudeep; Navadiya, Vijay; Dave, Ruchir; Deshmukh, Sandeep; Mishra, Vineet.
  • Kute VB; From the Department of Nephrology, Institute of Kidney Diseases and Research Centre, Dr HL Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India.
Exp Clin Transplant ; 19(12): 1263-1270, 2021 12.
Article in English | MEDLINE | ID: covidwho-1579964
ABSTRACT

OBJECTIVES:

Comparisons of COVID-19 incidence between kidney transplant recipients and patients who did not receive kidney transplant are underexplored in various geographic regions. MATERIALS AND

METHODS:

This Indian, single-center, retrospective study analyzed COVID-19 data of patients hospitalized between May 12, 2020, and January 11, 2021. A propensity matching score was used to compare outcomes between the 2 groups. We also used multivariable Cox proportional hazard analyses to assess association of kidney transplantation with mortality.

RESULTS:

Of the 1627 COVID-19 cases, 179 were kidney transplant recipients and 1448 were not kidney transplant patients (control group). Ofthe 436 reported in-hospital deaths, 20 (11.1%) were in the kidney transplant group and 416 (28.7%) were in the control group. Propensity matching identified 98 kidney transplantrecipients and167 controlpatients. InKaplanMeier survival plots for these patients, there was no statistical difference in mortality (log-rank, Mantel Cox test; P = .07) or severity (log-rank, Mantel Cox test; P = .07) with regard to COVID-19. In Cox analysis, age groups from 61 to 70 years (hazard ratio = 1.5; 95% CI, 1.0-2.2; P = .04), 71 to 80 years (hazard ratio = 1.64; 95% CI, 1.0-2.5; P = .02), and >80 years (hazard ratio = 1.91; 95% CI, 1.1-3.1; P = .01)were associatedwith statistically significant greater mortality.Having a kidney transplant (hazard ratio = 0.43; 95% CI, 0.3-0.7; P = 0.001) was not associated with mortality.

CONCLUSIONS:

In our analysis, age was the most important predictor of mortality. Kidney transplant status was not found to have an independent association with mortality and severity.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Humans / Middle aged Country/Region as subject: Asia Language: English Journal: Exp Clin Transplant Journal subject: Transplantation Year: 2021 Document Type: Article Affiliation country: Ect.2021.0438

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Humans / Middle aged Country/Region as subject: Asia Language: English Journal: Exp Clin Transplant Journal subject: Transplantation Year: 2021 Document Type: Article Affiliation country: Ect.2021.0438