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Single-Breath Counting Test Predicts Non-Invasive Respiratory Support Requirements in Patients with COVID-19 Pneumonia.
Longhitano, Yaroslava; Zanza, Christian; Romenskaya, Tatsiana; Saviano, Angela; Persiano, Tonia; Leo, Mirco; Piccioni, Andrea; Betti, Marta; Maconi, Antonio; Pindinello, Ivano; Boverio, Riccardo; Rello, Jordi; Franceschi, Francesco; Racca, Fabrizio.
  • Longhitano Y; Department of Anesthesiology and Intensive Care, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.
  • Zanza C; Foundation of "Ospedale Alba-Bra Onlus", 12060 Verduno, Italy.
  • Romenskaya T; Department of Emergency Medicine, Anesthesia and Critical Care Medicine, Michele and Pietro Ferrero Hospital, 12060 Verduno, Italy.
  • Saviano A; Department of Anesthesiology and Intensive Care, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.
  • Persiano T; Foundation of "Ospedale Alba-Bra Onlus", 12060 Verduno, Italy.
  • Leo M; Department of Emergency Medicine, Anesthesia and Critical Care Medicine, Michele and Pietro Ferrero Hospital, 12060 Verduno, Italy.
  • Piccioni A; Department of Emergency Medicine, Polyclinic Agostino Gemelli University Hospital, 00168 Rome, Italy.
  • Betti M; Department of Anesthesiology and Intensive Care, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.
  • Maconi A; Department of Emergency Medicine, Polyclinic Agostino Gemelli University Hospital, 00168 Rome, Italy.
  • Pindinello I; Department of Medicine and Emergency Medicine, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.
  • Boverio R; Department of Anesthesiology and Intensive Care, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.
  • Rello J; Department of Emergency Medicine, Polyclinic Agostino Gemelli University Hospital, 00168 Rome, Italy.
  • Franceschi F; Research Training Innovation Infrastructure, Research and Innovation Department, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.
  • Racca F; Research Training Innovation Infrastructure, Research and Innovation Department, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.
J Clin Med ; 11(1)2021 Dec 29.
Article in English | MEDLINE | ID: covidwho-1580635
ABSTRACT
The use of non-invasive respiratory strategies (NIRS) is crucial to improve oxygenation in COVID-19 patients with hypoxemia refractory to conventional oxygen therapy. However, the absence of respiratory symptoms may delay the start of NIRS. The aim of this study was to determine whether a simple bedside test such as single-breath counting test (SBCT) can predict the need for NIRS in the 24 h following the access to Emergency Department (ED). We performed a prospective observational study on 120 patients with COVID-19 pneumonia. ROC curves were used to analyze factors which might predict NIRS requirement. We found that 36% of patients had normal respiratory rate and did not experience dyspnea at rest. 65% of study population required NIRS in the 24 h following the access to ED. NIRS-requiring group presented lower PaO2/FiO2 (235.09 vs. 299.02), SpO2/FiO2 ratio (357.83 vs. 431.07), PaCO2 (35.12 vs. 40.08), and SBCT (24.46 vs. 30.36) and showed higher incidence of dyspnea at rest (57.7% vs. 28.6%). Furthermore, SBCT predicted NIRS requirement even in the subgroup of patients without respiratory symptoms (AUC = 0.882, cut-off = 30). SBCT might be a valuable tool for bedside assessment of respiratory function in patients with COVID-19 pneumonia and might be considered as an early clinical sign of impending respiratory deterioration.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm11010179

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm11010179