Entrectinib-A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells.
Int J Mol Sci
; 22(24)2021 Dec 18.
Article
in English
| MEDLINE | ID: covidwho-1580690
ABSTRACT
Since the start of the COVID-19 outbreak, pharmaceutical companies and research groups have focused on the development of vaccines and antiviral drugs against SARS-CoV-2. Here, we apply a drug repurposing strategy to identify drug candidates that are able to block the entrance of the virus into human cells. By combining virtual screening with in vitro pseudovirus assays and antiviral assays in Human Lung Tissue (HLT) cells, we identify entrectinib as a potential antiviral drug.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Benzamides
/
SARS-CoV-2
/
COVID-19 Drug Treatment
/
Indazoles
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Topics:
Traditional medicine
/
Vaccines
Limits:
Animals
/
Humans
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Ijms222413592
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