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H2S Donors and Their Use in Medicinal Chemistry.
Magli, Elisa; Perissutti, Elisa; Santagada, Vincenzo; Caliendo, Giuseppe; Corvino, Angela; Esposito, Gianluca; Esposito, Giovanna; Fiorino, Ferdinando; Migliaccio, Marco; Scognamiglio, Antonia; Severino, Beatrice; Sparaco, Rosa; Frecentese, Francesco.
  • Magli E; Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
  • Perissutti E; Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
  • Santagada V; Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
  • Caliendo G; Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
  • Corvino A; Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
  • Esposito G; Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
  • Esposito G; Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
  • Fiorino F; Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
  • Migliaccio M; Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
  • Scognamiglio A; Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
  • Severino B; Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
  • Sparaco R; Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
  • Frecentese F; Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
Biomolecules ; 11(12)2021 12 18.
Article in English | MEDLINE | ID: covidwho-1581038
ABSTRACT
Hydrogen sulfide (H2S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H2S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H2S levels has a potential therapeutic value. Consequently, synthetic H2S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H2S donors; furthermore, herein we discuss their preparation, the H2S-releasing mechanisms, and their -biological applications.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug Discovery / Gasotransmitters / Hydrogen Sulfide Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Biom11121899

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug Discovery / Gasotransmitters / Hydrogen Sulfide Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Biom11121899