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Cancer-Related Characteristics Associated With Invasive Mechanical Ventilation or In-Hospital Mortality in Patients With COVID-19 Admitted to ICU: A Cohort Multicenter Study.
Caruso, Pedro; Testa, Renato Scarsi; Freitas, Isabel Cristina Lima; Praça, Ana Paula Agnolon; Okamoto, Valdelis Novis; Santana, Pauliane Vieira; Costa, Ramon Teixeira; Kawasaki, Alexandre Melo; Fumis, Renata Rego Lins; Pino Illanes, Wilber Antonio; Costa, Eduardo Leite Vieira; Midega, Thais Dias; Correa, Thiago Domingos; de Carvalho, Fabrício Rodrigo Torres; Ferreira, Juliana Carvalho.
  • Caruso P; Intensive Care Unit, AC Camargo Cancer Center, Sao Paulo, Brazil.
  • Testa RS; Divisao de Pneumologia, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
  • Freitas ICL; Intensive Care Unit, AC Camargo Cancer Center, Sao Paulo, Brazil.
  • Praça APA; Intensive Care Unit, AC Camargo Cancer Center, Sao Paulo, Brazil.
  • Okamoto VN; Intensive Care Unit, AC Camargo Cancer Center, Sao Paulo, Brazil.
  • Santana PV; Intensive Care Unit, AC Camargo Cancer Center, Sao Paulo, Brazil.
  • Costa RT; Intensive Care Unit, AC Camargo Cancer Center, Sao Paulo, Brazil.
  • Kawasaki AM; Intensive Care Unit, AC Camargo Cancer Center, Sao Paulo, Brazil.
  • Fumis RRL; Intensive Care Unit, AC Camargo Cancer Center, Sao Paulo, Brazil.
  • Pino Illanes WA; Divisao de Pneumologia, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
  • Costa ELV; Hospital Sírio-Libanês, Research and Education Institute, Sao Paulo, Brazil.
  • Midega TD; Hospital Sírio-Libanês, Research and Education Institute, Sao Paulo, Brazil.
  • Correa TD; Divisao de Pneumologia, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
  • de Carvalho FRT; Hospital Sírio-Libanês, Research and Education Institute, Sao Paulo, Brazil.
  • Ferreira JC; Department of Critical Care Medicine, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
Front Oncol ; 11: 746431, 2021.
Article in English | MEDLINE | ID: covidwho-1581259
ABSTRACT

BACKGROUND:

Coexistence of cancer and COVID-19 is associated with worse outcomes. However, the studies on cancer-related characteristics associated with worse COVID-19 outcomes have shown controversial results. The objective of the study was to evaluate cancer-related characteristics associated with invasive mechanical ventilation use or in-hospital mortality in patients with COVID-19 admitted to intensive care unit (ICU).

METHODS:

We designed a cohort multicenter study including adults with active cancer admitted to ICU due to COVID-19. Seven cancer-related characteristics (cancer status, type of cancer, metastasis occurrence, recent chemotherapy, recent immunotherapy, lung tumor, and performance status) were introduced in a multilevel logistic regression model as first-level variables and hospital was introduced as second-level variable (random effect). Confounders were identified using directed acyclic graphs.

RESULTS:

We included 274 patients. Required to undergo invasive mechanical ventilation were 176 patients (64.2%) and none of the cancer-related characteristics were associated with mechanical ventilation use. Approximately 155 patients died in hospital (56.6%) and poor performance status, measured with the Eastern Cooperative Oncology Group (ECOG) score was associated with increased in-hospital mortality, with odds ratio = 3.54 (1.60-7.88, 95% CI) for ECOG =2 and odds ratio = 3.40 (1.60-7.22, 95% CI) for ECOG = 3 to 4. Cancer status, cancer type, metastatic tumor, lung cancer, and recent chemotherapy or immunotherapy were not associated with in-hospital mortality.

CONCLUSIONS:

In patients with active cancer and COVID-19 admitted to ICU, poor performance status was associated with in-hospital mortality but not with mechanical ventilation use. Cancer status, cancer type, metastatic tumor, lung cancer, and recent chemotherapy or immunotherapy were not associated with invasive mechanical ventilation use or in-hospital mortality.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Front Oncol Year: 2021 Document Type: Article Affiliation country: Fonc.2021.746431

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Front Oncol Year: 2021 Document Type: Article Affiliation country: Fonc.2021.746431