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The Effect of Isotonic Saline Nasal Lavages in Improving Symptoms in SARS-CoV-2 Infection: A Case-Control Study.
Spinato, Giacomo; Fabbris, Cristoforo; Costantini, Giulio; Conte, Federica; Scotton, Pier Giorgio; Cinetto, Francesco; De Siati, Rosalba; Matarazzo, Alessandro; Citterio, Marco; Contro, Giacomo; De Filippis, Cosimo; Agostini, Carlo; Emanuelli, Enzo; Boscolo-Rizzo, Paolo; Frezza, Daniele.
  • Spinato G; Department of Neurosciences, University of Padua, Padua, Italy.
  • Fabbris C; Department of Otolaryngology, Ospedale di Treviso, Treviso, Italy.
  • Costantini G; Department of Psychology, University of Milano-Bicocca, Milan, Italy.
  • Conte F; Department of Psychology, University of Milano-Bicocca, Milan, Italy.
  • Scotton PG; Department of Otolaryngology, Ospedale di Treviso, Treviso, Italy.
  • Cinetto F; Department of Neurosciences, University of Padua, Padua, Italy.
  • De Siati R; Department of Neurosciences, University of Padua, Padua, Italy.
  • Matarazzo A; Department of Neurosciences, University of Padua, Padua, Italy.
  • Citterio M; Department of Neurosciences, University of Padua, Padua, Italy.
  • Contro G; Department of Neurosciences, University of Padua, Padua, Italy.
  • De Filippis C; Department of Neurosciences, University of Padua, Padua, Italy.
  • Agostini C; Department of Neurosciences, University of Padua, Padua, Italy.
  • Emanuelli E; Department of Otolaryngology, Ospedale di Treviso, Treviso, Italy.
  • Boscolo-Rizzo P; Department of Otolaryngology, University of Trieste, Trieste, Italy.
  • Frezza D; Department of Otolaryngology, Ospedale di Treviso, Treviso, Italy.
Front Neurol ; 12: 794471, 2021.
Article in English | MEDLINE | ID: covidwho-1581261
ABSTRACT

Background:

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mainly colonizes nasopharynx. In upper airways acute infections, e.g., the common cold, saline nasal irrigations have a significant efficacy in reducing symptoms. The present study aimed to test the efficacy of nasal lavages in upper airways symptoms of Coronavirus Disease 2019 (COVID-19).

Methods:

A series of consecutive adult subjects who tested positive for SARS-CoV-2 from December 2020 to February 2021 performed daily nasal lavages with saline solution (Lavonase®-Purling, Lugo di Romagna, Italy) for 12 days, starting on the day after the SARS-CoV-2 positive swab. A control group included a historical series of patients who were infected in February-March 2020 and who did not perform lavages. An ad hoc questionnaire regarding symptoms was administered to each subjects at base-line and 10 days after diagnosis (i.e., on the same day of the control swab) in both cases and controls.

Results:

A total of 140 subjects were enrolled. 68 participants in the treatment group and 72 in the control group were included. 90% of respondents declared the lavages were simple to use and 70% declared they were satisfied. Symptoms of blocked nose, runny nose, or sneezing decreased by an average of 24.7% after the treatment. Blocked nose and sneezing increased in the same period of time in the control group. Ears and eyes symptoms, anosmia/ageusia symptoms, and infection duration (10.53 days in the treatment group and 10.48 days in the control group) didn't vary significantly among the two groups.

Conclusion:

Nasal lavages resulted to significantly decrease nasal symptoms in newly diagnosed SARS-CoV-2 patients. These devices proved to be well-tolerated and easy to be used. Further studies on a larger number of subjects are needed in order to possibly confirm these preliminary results.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Observational study / Randomized controlled trials Language: English Journal: Front Neurol Year: 2021 Document Type: Article Affiliation country: Fneur.2021.794471

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Observational study / Randomized controlled trials Language: English Journal: Front Neurol Year: 2021 Document Type: Article Affiliation country: Fneur.2021.794471