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The Humoral Immune Response to BNT162b2 Vaccine Is Associated With Circulating CD19+ B Lymphocytes and the Naïve CD45RA to Memory CD45RO CD4+ T Helper Cells Ratio in Hemodialysis Patients and Kidney Transplant Recipients.
Duni, Anila; Markopoulos, Georgios S; Mallioras, Ioannis; Pappas, Haralampos; Pappas, Efthymios; Koutlas, Vasileios; Tzalavra, Eirini; Baxevanos, Gerasimos; Priska, Silvia; Gartzonika, Konstantina; Mitsis, Michael; Dounousi, Evangelia.
  • Duni A; Department of Nephrology, University Hospital of Ioannina, Ioannina, Greece.
  • Markopoulos GS; Department of Surgery and Kidney Transplant Unit, University Hospital of Ioannina, Ioannina, Greece.
  • Mallioras I; Laboratory of Hematology - Unit of Molecular Biology, University Hospital of Ioannina, Ioannina, Greece.
  • Pappas H; Department of Nephrology, University Hospital of Ioannina, Ioannina, Greece.
  • Pappas E; Department of Nephrology, University Hospital of Ioannina, Ioannina, Greece.
  • Koutlas V; Department of Surgery and Kidney Transplant Unit, University Hospital of Ioannina, Ioannina, Greece.
  • Tzalavra E; Renal Unit, General Hospital of Filiates, Filiates, Greece.
  • Baxevanos G; Department of Surgery and Kidney Transplant Unit, University Hospital of Ioannina, Ioannina, Greece.
  • Priska S; Department of Surgery and Kidney Transplant Unit, University Hospital of Ioannina, Ioannina, Greece.
  • Gartzonika K; Laboratory of Hematology - Unit of Molecular Biology, University Hospital of Ioannina, Ioannina, Greece.
  • Mitsis M; Internal Medicine Department, Hatzikosta General Hospital of Ioannina, Ioannina, Greece.
  • Dounousi E; Department of Nephrology, School of Medicine, University of Ioannina, Ioannina, Greece.
Front Immunol ; 12: 760249, 2021.
Article in English | MEDLINE | ID: covidwho-1581341
ABSTRACT

Background:

The humoral and cellular immune responses to SARS-COV-2 vaccination remain to be elucidated in hemodialysis (HD) patients and kidney transplant recipients (KTRs), considering their baseline immunosuppressed status. The aim of our study was to assess the associations of vaccine-induced antibody responses with circulating lymphocytes sub-populations and their respective patterns of alterations in maintenance HD patients and KTRs. Materials and

Methods:

We included 34 HD patients and 54 KTRs who received two doses of the mRNA-vaccine BNT162b2. Lymphocyte subpopulations were analyzed by flow cytometry before vaccination (T0), before the second vaccine dose (T1) and 2 weeks after the second dose (T2). The anti-SARS-CoV2 antibody response was assessed at T1 and at T2.

Results:

31 HD patients (91.8%) and 16 KTRs (29.6%) became seropositive at T2. HD patients who became seropositive following the first dose displayed higher CD19+ B lymphocytes compared to their seronegative HD counterparts. A positive correlation was established between CD19+ B cells counts and antibody titers at all time-points in both groups (p < 0.001). KTRs showed higher naïve CD4+CD45RA+ T helper cells compared to HD patients at baseline and T2 whereas HD patients displayed higher memory CD45RO+ T cells compared to KTRs at T2. The naïve CD4+CD45RA to memory CD4+CD45RO+ T helper cells fraction was negatively associated with antibody production in both groups.

Conclusions:

Our study provides a potential conceptual framework for monitoring vaccination efficacy in HD patients and KTRs considering the correlation established between CD19+ B cells, generation of memory CD4+ T helper cells and anti SARS-CoV2 antibody response to vaccination.
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Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: B-Lymphocytes / CD4-Positive T-Lymphocytes / Immunocompromised Host / Immunity, Humoral / BNT162 Vaccine / Immunologic Memory / Antibody Formation Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Female / Humans / Male Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.760249

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Full text: Available Collection: International databases Database: MEDLINE Main subject: B-Lymphocytes / CD4-Positive T-Lymphocytes / Immunocompromised Host / Immunity, Humoral / BNT162 Vaccine / Immunologic Memory / Antibody Formation Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Female / Humans / Male Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.760249