Acute triiodothyronine treatment and red blood cell sedimentation rate (ESR) in critically ill COVID-19 patients: A novel association?
Clin Hemorheol Microcirc
; 79(3): 485-488, 2021.
Article
in English
| MEDLINE | ID: covidwho-1581405
ABSTRACT
Sepsis and septic shock result in impaired microcirculation and red blood cell rheology which lead to tissue hypoxia and multi-organ failure. Early administration of triiodothyronine prevents tissue hypoxia in experimental sepsis. In this context, a clinical trial was initiated to test the efficacy of acute triiodothyronine administration to combat tissue hypoxia in critically ill COVID19 patients. Here, we provide preliminary data from interim analysis of this study showing a novel acute effect of triiodothyronine on erythrocyte sedimentation rate which may have an important therapeutic impact on red blood cell rheology and tissue hypoxia in sepsis and particular in COVID19 critical illness.Trial registration ClinicalTrials.gov, NCT04348513. Registered 16 April 2020, https//clinicaltrials.gov/ct2/show/NCT04348513.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Shock, Septic
/
Sepsis
/
COVID-19
Type of study:
Prognostic study
/
Randomized controlled trials
Limits:
Humans
Language:
English
Journal:
Clin Hemorheol Microcirc
Journal subject:
Vascular Diseases
/
Hematology
Year:
2021
Document Type:
Article
Affiliation country:
Ch-211215
Similar
MEDLINE
...
LILACS
LIS