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A systematic review and meta-analysis of the sensitivity of antibody tests for the laboratory confirmation of COVID-19.
Makoah, Nigel A; Tipih, Thomas; Litabe, Matefo M; Brink, Mareza; Sempa, Joseph B; Goedhals, Dominique; Burt, Felicity J.
  • Makoah NA; Division of Virology, Faculty of Health Sciences, University of The Free State, Bloemfontein, 9301, South Africa.
  • Tipih T; Division of Virology, Faculty of Health Sciences, University of The Free State, Bloemfontein, 9301, South Africa.
  • Litabe MM; Division of Virology, Faculty of Health Sciences, University of The Free State, Bloemfontein, 9301, South Africa.
  • Brink M; Free State Department of Health, Bloemfontein, 9301, South Africa.
  • Sempa JB; Department of Biostatistics, Faculty of Health Sciences, University of The Free State, Bloemfontein, 9301, South Africa.
  • Goedhals D; DST-NRF Centre of Excellence in Epidemiological Modelling & Analysis (SACEMA), Stellenbosch University, Stellenbosch, 7600, South Africa.
  • Burt FJ; Division of Virology, Faculty of Health Sciences, University of The Free State, Bloemfontein, 9301, South Africa.
Future Virol ; 2021 Nov.
Article in English | MEDLINE | ID: covidwho-1581482
ABSTRACT

Aim:

The aim of this study was to investigate the utility of serological tests for the diagnosis of COVID-19 during the first week of symptom onset in patients confirmed with the real-time RT-PCR. Materials &

methods:

A systematic review and meta-analysis of 58 publications were performed using data obtained from Academic Search Ultimate, Africa-wide, Scopus, Web of Science and MEDLINE.

Results:

We found that the highest pooled sensitivities were obtained with ELISA IgM-IgG and chemiluminescence immunoassay IgM tests.

Conclusion:

Serological tests have low sensitivity within the first week of symptom onset and cannot replace nucleic acid amplification tests. However, serological assays can be used to support nucleic acid amplification tests.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Reviews / Systematic review/Meta Analysis Language: English Year: 2021 Document Type: Article Affiliation country: Fvl-2021-0211

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Reviews / Systematic review/Meta Analysis Language: English Year: 2021 Document Type: Article Affiliation country: Fvl-2021-0211