Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection.
Mol Med
; 27(1): 162, 2021 12 27.
Article
in English
| MEDLINE | ID: covidwho-1582120
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is critically important to define the immunological processes occurring in the human response to this virus and pathogenetic mechanisms of its deadly manifestation. This perspective focuses on the contribution of the recently discovered interaction of SARS-CoV-2 Spike protein with neuropilin 1 (NRP1) receptor, NRP1 as a virus entry receptor for SARS-CoV-2, its role in different physiologic and pathologic conditions, and the potential to target the Spike-NRP1 interaction to combat virus infectivity and severe disease manifestations.
Keywords
ACE2, angiotensin converting enzyme 2; COVID-19, coronavirus disease 2019; CendR C-end rule; Comorbidities; Host immune response; Immunotargets and strategies; Molecular structures; NRP-1, neuropilin-1; RBD, receptor-biding domain; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; Spike protein
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Neuropilin-1
/
COVID-19 Drug Treatment
Type of study:
Observational study
Limits:
Female
/
Humans
/
Infant
/
Pregnancy
Language:
English
Journal:
Mol Med
Journal subject:
Molecular Biology
Year:
2021
Document Type:
Article
Affiliation country:
S10020-021-00423-Y
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