Your browser doesn't support javascript.
An outbreak of SARS-CoV-2 on a transplant unit in the early vaccination era.
Roberts, Scott C; Foppiano Palacios, Carlo; Grubaugh, Nathan D; Alpert, Tara; Ott, Isabel M; Breban, Mallery I; Martinello, Richard A; Smith, Cindy; Davis, Matthew W; Mcmanus, Dayna; Tirmizi, Samad; Topal, Jeffrey E; Azar, Marwan M; Malinis, Maricar.
  • Roberts SC; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
  • Foppiano Palacios C; Department of Infection Prevention, Yale New Haven Health, New Haven, Connecticut, USA.
  • Grubaugh ND; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
  • Alpert T; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.
  • Ott IM; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.
  • Breban MI; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.
  • Smith C; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
  • Davis MW; Department of Infection Prevention, Yale New Haven Health, New Haven, Connecticut, USA.
  • Mcmanus D; Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA.
  • Tirmizi S; Department of Infection Prevention, Yale New Haven Health, New Haven, Connecticut, USA.
  • Topal JE; Department of Pharmacy Services, Yale New Haven Hospital, New Haven, Connecticut, USA.
  • Azar MM; Department of Pharmacy Services, Yale New Haven Hospital, New Haven, Connecticut, USA.
  • Malinis M; Department of Pharmacy Services, Yale New Haven Hospital, New Haven, Connecticut, USA.
Transpl Infect Dis ; 24(2): e13782, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1583252
ABSTRACT

BACKGROUND:

Solid organ transplant recipients are at increased risk of COVID-19-associated morbidity and mortality.

AIMS:

We describe a nosocomial outbreak investigation on an immunocompromised inpatient unit.

METHODS:

Patients positive for SARS-CoV-2 were identified. An epidemiologic investigation was assisted with whole genome sequencing of positive samples.

RESULTS:

Two patients were identified as potential index cases; one presented with diarrhea and was initially not isolated, and the other developed hypoxemia on hospital day 18 before testing positive. Following identification of a SARS-CoV-2 cluster, the unit was closed and all patients and staff received surveillance testing revealing eight additional positive patients and staff members. Whole genome sequencing confirmed an outbreak. Enhanced infection prevention practices mitigated further spread. Asymptomatic patients with COVID-19 were successfully treated with bamlanivimab.

DISCUSSION:

Preventing SARS-CoV-2 outbreaks in transplant units poses unique challenges as patients may have atypical presentations of COVID-19. Immunocompromised patients who test positive for SARS-CoV-2 while asymptomatic may benefit from monoclonal antibody therapy to prevent disease progression. All hospital staff members working with immunocompromised patients should be promptly encouraged to follow infection prevention behaviors and receive SARS-CoV-2 vaccination.

CONCLUSION:

SARS-CoV-2 outbreaks on immunocompromised units can be mitigated through prompt identification of cases and robust infection prevention practices.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Transpl Infect Dis Journal subject: Transplantation Year: 2022 Document Type: Article Affiliation country: Tid.13782

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Transpl Infect Dis Journal subject: Transplantation Year: 2022 Document Type: Article Affiliation country: Tid.13782