The effectiveness of the combined use of remdesivir and regdanvimab (CT-P59) in patients with severe COVID-19: A single center retrospective study
Respirology
; 26(SUPPL 3):23-24, 2021.
Article
in English
| EMBASE | ID: covidwho-1583451
ABSTRACT
Background:
Although the use of remdesivir and systemic corticosteroids have reduced deaths from COVID-19, COVID-19 still has a high mortality rate.Aims:
To know the effectiveness of the combined use of remdesivir and regdanvimab (CT-P59) in patients with severe COVID-19.Methods:
From March to early May 2021, 124 severe COVID-19 patients were admitted to Ulsan University Hospital (Ulsan, Korea), and received oxygen therapy and remdesivir. Among them, 25 were administered regdanvimab before oxygen/remdesivir. We retrospectively compared the outcomes of the two groups remdesivir alone group (n = 99 [79.8%]) vs. regdanvimab/remdesivir group (n = 25 [20.2%]).Results:
The oxygen-free days at day 28 (primary outcome), defined as the number of days a patient was alive and oxygen-free for 28 days from oxygen/remdesivir start, were significantly higher in regdanvimab/remdesivir group (mean ± SD [standard deviation] 19.36 ± 7.87 vs. 22.72 ± 3.66, P = 0.003). The association between the regdanvimab/ remdesivir group and the oxygen-free days was also significant in multivariate analysis (logistic regression), where the initial SpO2/FiO2 ratio (severity index) was adjusted. Further, in the regdanvimab/remdesivir group, the lowest SpO2/FiO2 ratio during treatment was significantly higher (mean ± SD 237.05 ± 89.68 vs. 295.63 ± 72.74, P = 0.003), and the Kaplan-Meier Estimate of oxygen supplement days in surviving patients (at day 28) were significantly shorter (mean ± SD 8.24 ± 7.43 vs. 5.28 ± 3.66, P (log-rank test) = 0.024).Conclusions:
In severe COVID-19 patients, clinical outcomes could be improved by using regdanvimab in addition to remdesivir.
oxygen; regdanvimab; remdesivir; adult; clinical, outcome; conference, abstract; controlled, study; coronavirus, disease, 2019; drug, combination; drug, therapy; female; fraction, of, inspired, oxygen; human; Kaplan, Meier, method; Korea; log, rank, test; major, clinical, study; male; oxygen, therapy; retrospective, study; university, hospital
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
/
Observational study
Language:
English
Journal:
Respirology
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS