HbA1c level may be a risk factor for oxygen therapy requirement in patients with coronavirus disease 2019.
J Diabetes Investig
; 13(5): 909-917, 2022 May.
Article
in English
| MEDLINE | ID: covidwho-1583509
ABSTRACT
INTRODUCTION:
Many clinical studies have identified significant predictors or risk factors for the severity or mortality of coronavirus disease 2019 (COVID-19) cases. However, there are very limited reports on the risk factors for requiring oxygen therapy during hospitalization. In particular, we sought to investigate whether plasma glucose and HbA1c levels could be risk factors for oxygen therapy requirement. MATERIALS ANDMETHODS:
A single-center, retrospective study was conducted of 131 COVID-19 patients hospitalized at Saitama Medical University Hospital between March 2020 and November 2020. To identify the risk factors for oxygen therapy requirement during hospitalization, a stepwise multivariate binary logistic regression analysis was performed using several clinical parameters commonly obtained on admission, including plasma glucose and HbA1c levels.RESULTS:
Of the 131 patients with COVID-19, 33.6% (44/131) received oxygen therapy during hospitalization. According to the logistic regression analysis, male sex (odds ratio [OR] 8.76, 95% confidence interval [CI] 1.65-46.5, P < 0.05), age (OR 1.07, 95% CI 1.02-1.12, P < 0.01), HbA1c levels (OR 1.94, 95% CI 1.09-3.44, P < 0.05), and serum C-reactive protein (CRP) levels (OR 2.22, 95% CI 1.54-3.20, P < 0.01) emerged as independent variables associated with oxygen therapy requirement during hospitalization.CONCLUSIONS:
In addition to male sex, age, and serum CRP levels, HbA1c levels on admission may serve as a risk factor for oxygen therapy requirement during the clinical course of COVID-19, irrespective of diabetes history and status. This may contribute to the efficient delegation of limited numbers of hospital beds to patients at risk for oxygen therapy requirement.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
/
Male
Language:
English
Journal:
J Diabetes Investig
Year:
2022
Document Type:
Article
Affiliation country:
Jdi.13743
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