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SARS-CoV-2 infections in households in a peri-urban community of Lima, Peru: A prospective cohort study.
Lanata, Claudio F; Gil, Ana I; Ecker, Lucie; Cornejo, Rubelio; Rios, Stefano; Ochoa, Mayra; Peña, Bia; Flores, Omar; Howard, Leigh M; Grijalva, Carlos G.
  • Lanata CF; Instituto de Investigación Nutricional, Lima, Peru.
  • Gil AI; Vanderbilt University, Nashville, Tennessee, USA.
  • Ecker L; London School of Hygiene and Tropical Medicine, London, UK.
  • Cornejo R; Instituto de Investigación Nutricional, Lima, Peru.
  • Rios S; Instituto de Investigación Nutricional, Lima, Peru.
  • Ochoa M; Instituto de Investigación Nutricional, Lima, Peru.
  • Peña B; Instituto de Investigación Nutricional, Lima, Peru.
  • Flores O; Instituto de Investigación Nutricional, Lima, Peru.
  • Howard LM; Instituto de Investigación Nutricional, Lima, Peru.
  • Grijalva CG; Instituto de Investigación Nutricional, Lima, Peru.
Influenza Other Respir Viruses ; 16(3): 386-394, 2022 05.
Article in English | MEDLINE | ID: covidwho-1583523
ABSTRACT

BACKGROUND:

We assessed the prevalence and incidence of SARS-CoV-2 infections in a prospective study of households in Lima, Peru.

METHODS:

Households with a child, a young adult 18-50 years, and an adult age >50 years in peri-urban Lima were followed with twice-a-week household visits during a 2-month period. Nasal swabs and saliva specimens were collected twice weekly, and nasopharyngeal swabs were collected weekly from each participant, regardless of symptoms. Laboratory-confirmed SARS-CoV-2 infection was defined by two RT-PCR tests from any of the collected specimens within a week. Blood samples collected at enrollment and end of follow-up were tested with rapid serological tests. We calculated the prevalence and incidence of laboratory-confirmed SARS-CoV-2 infections.

RESULTS:

We enrolled 132 participants from 44 households 44 children, 44 young adults, and 44 older adults. A total of 13 SARS-CoV-2 infections were detected in eight households, for an overall period prevalence of 9.85% (95% confidence interval [CI] 5.35-16.25). Most (61.54%) infections were symptomatic. Eight of 11 (72.73%) SARS-CoV-2 detections corresponded to the Lambda variant. During 218.79 person-months at risk of follow-up, there were six new SARS-CoV-2 infections detected (2.74 per 100 person-month, 95% CI 1.25-6.04). At enrollment, 59 of 128 participants tested had positive SARS-CoV-2 IgG serology (46.09%, 95% CI 37.25-55.12). Five of six new infections occurred among participants with negative baseline serology.

CONCLUSIONS:

We demonstrated high incidence of SARS-CoV-2 infections in households, especially among subjects without evidence of prior infection, most of them not detected by the Ministry of Health system.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Variants Limits: Adult / Aged / Child / Humans / Middle aged / Young adult Country/Region as subject: South America / Peru Language: English Journal: Influenza Other Respir Viruses Journal subject: Virology Year: 2022 Document Type: Article Affiliation country: Irv.12952

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Variants Limits: Adult / Aged / Child / Humans / Middle aged / Young adult Country/Region as subject: South America / Peru Language: English Journal: Influenza Other Respir Viruses Journal subject: Virology Year: 2022 Document Type: Article Affiliation country: Irv.12952