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Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry.
Bhalala, Utpal S; Gist, Katja M; Tripathi, Sandeep; Boman, Karen; Kumar, Vishakha K; Retford, Lynn; Chiotos, Kathleen; Blatz, Allison M; Dapul, Heda; Verma, Sourabh; Sayed, Imran A; Gharpure, Varsha P; Bjornstad, Erica; Tofil, Nancy; Irby, Katherine; Sanders, Ronald C; Heneghan, Julia A; Thomas, Melissa; Gupta, Manoj K; Oulds, Franscene E; Arteaga, Grace M; Levy, Emily R; Gupta, Neha; Kaufman, Margit; Abdelaty, Amr; Shlomovich, Mark; Medar, Shivanand S; Iqbal O'Meara, A M; Kuehne, Joshua; Menon, Shina; Khandhar, Paras B; Miller, Aaron S; Barry, Suzanne M; Danesh, Valerie C; Khanna, Ashish K; Zammit, Kimberly; Stulce, Casey; McGonagill, Patrick W; Bercow, Asher; Amzuta, Ioana G; Gupta, Sandeep; Almazyad, Mohammed A; Pierre, Louisdon; Sendi, Prithvi; Ishaque, Sidra; Anderson, Harry L; Nawathe, Pooja; Akhter, Murtaza; Lyons, Patrick G; Chen, Catherine.
  • Bhalala US; The Children's Hospital of San Antonio, San Antonio, TX.
  • Gist KM; Baylor College of Medicine, Houston, TX.
  • Tripathi S; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, CO.
  • Boman K; Children's Hospital of Illinois, OSF St Francis Medical Centre, Peoria, IL.
  • Kumar VK; Society of Critical Care Medicine, Mount Prospect, IL.
  • Retford L; Society of Critical Care Medicine, Mount Prospect, IL.
  • Chiotos K; Society of Critical Care Medicine, Mount Prospect, IL.
  • Blatz AM; Children's Hospital of Philadelphia, Philadelphia, PA.
  • Dapul H; Children's Hospital of Philadelphia, Philadelphia, PA.
  • Verma S; Hassenfeld Children's Hospital at NYU Langone, New York, NY.
  • Sayed IA; Hassenfeld Children's Hospital at NYU Langone, New York, NY.
  • Gharpure VP; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, CO.
  • Bjornstad E; Advocate Children's Hospital, Park Ridge, IL.
  • Tofil N; Children's Hospital Alabama, Birmingham, AL.
  • Irby K; Children's Hospital Alabama, Birmingham, AL.
  • Sanders RC; Arkansas Children's Hospital, Little Rock, AR.
  • Heneghan JA; Arkansas Children's Hospital, Little Rock, AR.
  • Thomas M; University of Minnesota Masonic Children's Hospital, Minneapolis, MN.
  • Gupta MK; Norton Children's Hospital, Louisville, KY.
  • Oulds FE; Lincoln Medical Center, Bronx, NY.
  • Arteaga GM; Children's Hospital at Montefiore, Bronx, NY.
  • Levy ER; Lincoln Medical Center, Bronx, NY.
  • Gupta N; Mayo Clinic, Rochester, MN.
  • Kaufman M; Mayo Clinic, Rochester, MN.
  • Abdelaty A; University of Oklahoma Health Sciences Center, Oklahoma City, OK.
  • Shlomovich M; Englewood Health, Englewood, NJ.
  • Medar SS; Englewood Health, Englewood, NJ.
  • Iqbal O'Meara AM; Children's Hospital at Montefiore, Bronx, NY.
  • Kuehne J; Children's Hospital at Montefiore, Bronx, NY.
  • Menon S; Children's Hospital of Richmond at VCU, Richmond, VA.
  • Khandhar PB; The Children's Hospital of San Antonio, San Antonio, TX.
  • Miller AS; Seattle Children's Hospital, Seattle, WA.
  • Barry SM; Beaumont Children's Hospital, Beaumont, MI.
  • Danesh VC; Cardinal Glennon Children's Hospital, Saint Louis, MO.
  • Khanna AK; Bernard and Millie Duker Children's Hospital at Albany Medical Center, Albany, NY.
  • Zammit K; Baylor Scott and White Health, Temple, TX.
  • Stulce C; Wake Forest University School of Medicine, Winston-Salem, NC.
  • McGonagill PW; The Outcomes Research Consortium, Cleveland, OH.
  • Bercow A; John R. Oishei Children's Hospital, Buffalo, NY.
  • Amzuta IG; University of Chicago, Chicago, IL.
  • Gupta S; University of Iowa, Iowa City, IA.
  • Almazyad MA; Jacobi Medical Center, Bronx, NY.
  • Pierre L; SUNY Upstate University Hospital, Syracuse, NY.
  • Sendi P; Community Health Network, Indianapolis, IN.
  • Ishaque S; Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
  • Anderson HL; The Brooklyn Hospital Center, Brooklyn, NY.
  • Nawathe P; Nicklaus Children's Hospital, Miami, FL.
  • Akhter M; The Aga Khan University Hospital, Karachi, Pakistan.
  • Lyons PG; St. Joseph Mercy, Ann Arbor, MI.
  • Chen C; Cedar-Sinai Medical Center, Los Angeles, CA.
Crit Care Med ; 50(1): e40-e51, 2022 01 01.
Article in English | MEDLINE | ID: covidwho-1584019
ABSTRACT

OBJECTIVES:

Multicenter data on the characteristics and outcomes of children hospitalized with coronavirus disease 2019 are limited. Our objective was to describe the characteristics, ICU admissions, and outcomes among children hospitalized with coronavirus disease 2019 using Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study Coronavirus Disease 2019 registry.

DESIGN:

Retrospective study.

SETTING:

Society of Critical Care Medicine Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) registry. PATIENTS Children (< 18 yr) hospitalized with coronavirus disease 2019 at participating hospitals from February 2020 to January 2021.

INTERVENTIONS:

None. MEASUREMENTS AND MAIN

RESULTS:

The primary outcome was ICU admission. Secondary outcomes included hospital and ICU duration of stay and ICU, hospital, and 28-day mortality. A total of 874 children with coronavirus disease 2019 were reported to Viral Infection and Respiratory Illness Universal Study registry from 51 participating centers, majority in the United States. Median age was 8 years (interquartile range, 1.25-14 yr) with a malefemale ratio of 12. A majority were non-Hispanic (492/874; 62.9%). Median body mass index (n = 817) was 19.4 kg/m2 (16-25.8 kg/m2), with 110 (13.4%) overweight and 300 (36.6%) obese. A majority (67%) presented with fever, and 43.2% had comorbidities. A total of 238 of 838 (28.2%) met the Centers for Disease Control and Prevention criteria for multisystem inflammatory syndrome in children, and 404 of 874 (46.2%) were admitted to the ICU. In multivariate logistic regression, age, fever, multisystem inflammatory syndrome in children, and pre-existing seizure disorder were independently associated with a greater odds of ICU admission. Hospital mortality was 16 of 874 (1.8%). Median (interquartile range) duration of ICU (n = 379) and hospital (n = 857) stay were 3.9 days (2-7.7 d) and 4 days (1.9-7.5 d), respectively. For patients with 28-day data, survival was 679 of 787, 86.3% with 13.4% lost to follow-up, and 0.3% deceased.

CONCLUSIONS:

In this observational, multicenter registry of children with coronavirus disease 2019, ICU admission was common. Older age, fever, multisystem inflammatory syndrome in children, and seizure disorder were independently associated with ICU admission, and mortality was lower among children than mortality reported in adults.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Child, Hospitalized / Systemic Inflammatory Response Syndrome / COVID-19 Type of study: Controlled clinical trial / Observational study / Prognostic study / Risk factors Topics: Long Covid Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: Crit Care Med Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Child, Hospitalized / Systemic Inflammatory Response Syndrome / COVID-19 Type of study: Controlled clinical trial / Observational study / Prognostic study / Risk factors Topics: Long Covid Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: Crit Care Med Year: 2022 Document Type: Article