Colon capsule endoscopy versus computed tomographic colonography for identifying colorectal cancer and polyps: A systemic review and meta-analysis
British Journal of Surgery
; 108(SUPPL 7):vii118, 2021.
Article
in English
| EMBASE | ID: covidwho-1585079
ABSTRACT
Aim:
Early diagnosis and treatment of Colorectal Cancer can improve outcomes. Polypectomy with colonoscopy has failure and incompletion rates with risk of aerosol-generation. Computed Tomographic Colonography, second investigation, is limited by radiation exposure and aerosol generation. Colon Capsule endoscopy is a novel technique without gas insufflation, therefore avoiding the discomfort and aerosol- generation. Our aim is to compare the yield of the CCE with CTC in CRC and polyps in patients with positive stool tests or diagnosed colorectal lesions.Methods:
Review followed PRISMA standards. Electronic database (EMBASE, MEDLINE, PubMed, CINAHL) searched for RCTs and Observational studies. MedCalc Statistical Software used for the synthesis of results. Primary (Per-Lesion and Per-Patient sensitivity analysis) and secondary (Other lesion and completion rate sensitivity analysis) outcomes measured using a random-effect model.Results:
We found one RCT and three observational studies. Per-Lesion Sensitivity Analysis of CCE versus CTC showed overall effect of 1.903 (0.990- 1.937), p-value-0.057. Per-Patient Sensitivity Analysis of showed overall effect of 1.928 (0.995-1.892), p-value-0.054. Other lesions Sensitivity Analysis showed overall effect of 0.810 (0.121-161.995), pvalue- 0.418. Completion Rate Sensitivity Analysis showed overall effect of -0.419 (0.526-1.516), p-value-0.676.Conclusion:
CCE had a better detection rate for colorectal cancer and polyp than the CTC, but this was not statistically significant. Therefore, this study failed to prove CCE's superiority over CTC. A careful decision can be made in current COVID-19 pandemic since its advantage of zero aerosolisation. Researchers should focus on innovation in techniques and simultaneous high-quality studies to evaluate them.
adult; aeration; aerosol; cancer, patient; Cinahl; colon, capsule, endoscopy; colon, injury; colorectal, cancer; computed, tomographic, colonography; conference, abstract; controlled, study; coronavirus, disease, 2019; data, analysis, software; diagnosis; early, diagnosis; Embase; feces, analysis; female; human; male; Medline; observational, study; pandemic; polyp; polypectomy; radiation, exposure; sensitivity, analysis; synthesis; systematic, review
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Reviews
Language:
English
Journal:
British Journal of Surgery
Year:
2021
Document Type:
Article
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