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Hypermetabolic abdominal and cervical lymph nodes mimicking Hodgkin lymphoma relapse on FDG PET/CT after adenovirus-vectored COVID-19 vaccine.
Landete, Elena; Gómez-Fernández, Isabel; González-Gascón-Y-Marín, Isabel; Durán-Barquero, Carmen; Churruca, Juan; Infante, María-Stefania; Muñoz-Novas, Carolina; Foncillas, María-Ángeles; Marín, Karen; Ramos-de-Ascanio, Victoria; Alonso-Farto, Juan Carlos; Hernández-Rivas, José-Ángel.
  • Landete E; Servicio de Hematología, Hospital Universitario Infanta Leonor, Madrid, Spain.
  • Gómez-Fernández I; Servicio de Medicina Nuclear, Hospital Universitario Gregorio Marañón, Madrid, Spain.
  • González-Gascón-Y-Marín I; Servicio de Hematología, Hospital Universitario Infanta Leonor, Madrid, Spain.
  • Durán-Barquero C; Servicio de Medicina Nuclear, Hospital Universitario Gregorio Marañón, Madrid, Spain.
  • Churruca J; Servicio de Hematología, Hospital Universitario Infanta Leonor, Madrid, Spain.
  • Infante MS; Servicio de Hematología, Hospital Universitario Infanta Leonor, Madrid, Spain.
  • Muñoz-Novas C; Servicio de Hematología, Hospital Universitario Infanta Leonor, Madrid, Spain.
  • Foncillas MÁ; Servicio de Hematología, Hospital Universitario Infanta Leonor, Madrid, Spain.
  • Marín K; Servicio de Hematología, Hospital Universitario Infanta Leonor, Madrid, Spain.
  • Ramos-de-Ascanio V; Servicio de Hematología, Hospital Universitario Infanta Leonor, Madrid, Spain.
  • Alonso-Farto JC; Servicio de Medicina Nuclear, Hospital Universitario Gregorio Marañón, Madrid, Spain.
  • Hernández-Rivas JÁ; Servicio de Hematología, Hospital Universitario Infanta Leonor, Madrid, Spain.
Hum Vaccin Immunother ; 17(12): 5129-5132, 2021 Dec 02.
Article in English | MEDLINE | ID: covidwho-1585257
ABSTRACT
Vaccine-associated hypermetabolic lymphadenopathy (VAHL) has been reported as a common post-vaccination side effect, especially with mRNA-based COVID-19 vaccines. Most VAHL cases present normal or enlarged regional lymph nodes close to the injection site, usually with mild-moderate FDG (18 F-Fluorodeoxyglucose) uptake on FDG positron emission tomography (PET)/CT. Here, we describe the case of a 33-year-old woman with past history of Classic Hodgkin Lymphoma (CHL) who underwent follow-up FDG PET/CT 3 days (d) after the first dose of the adenovirus-vectored Oxford-AstraZeneca COVID-19 vaccine. FDG PET/CT showed unexpected small hypermetabolic cervical and abdominal lymph nodes in the same location as at the onset of the disease, suggesting radiological relapse. Considering temporal relationship and other cases of VAHL, a new image was performed 2 months later, which revealed decreased lymph nodes and normalization of FDG uptake. This case illustrates that the possibility of a false-positive should always be considered by physicians in this new context, even when hypermetabolic lymph nodes appear far from the vaccination site.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hodgkin Disease / COVID-19 Type of study: Case report / Cohort study / Observational study / Prognostic study Topics: Vaccines / Variants Limits: Adult / Female / Humans Language: English Journal: Hum Vaccin Immunother Year: 2021 Document Type: Article Affiliation country: 21645515.2021.2008215

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hodgkin Disease / COVID-19 Type of study: Case report / Cohort study / Observational study / Prognostic study Topics: Vaccines / Variants Limits: Adult / Female / Humans Language: English Journal: Hum Vaccin Immunother Year: 2021 Document Type: Article Affiliation country: 21645515.2021.2008215