Single-cell immunology of SARS-CoV-2 infection.
Nat Biotechnol
; 40(1): 30-41, 2022 01.
Article
in English
| MEDLINE | ID: covidwho-1585828
ABSTRACT
Gaining a better understanding of the immune cell subsets and molecular factors associated with protective or pathological immunity against severe acute respiratory syndrome coronavirus (SARS-CoV)-2 could aid the development of vaccines and therapeutics for coronavirus disease 2019 (COVID-19). Single-cell technologies, such as flow cytometry, mass cytometry, single-cell transcriptomics and single-cell multi-omic profiling, offer considerable promise in dissecting the heterogeneity of immune responses among individual cells and uncovering the molecular mechanisms of COVID-19 pathogenesis. Single-cell immune-profiling studies reported to date have identified innate and adaptive immune cell subsets that correlate with COVID-19 disease severity, as well as immunological factors and pathways of potential relevance to the development of vaccines and treatments for COVID-19. For facilitation of integrative studies and meta-analyses into the immunology of SARS-CoV-2 infection, we provide standardized, download-ready versions of 21 published single-cell sequencing datasets (over 3.2 million cells in total) as well as an interactive visualization portal for data exploration.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Single-Cell Analysis
/
Datasets as Topic
/
Data Visualization
/
SARS-CoV-2
/
COVID-19
/
Immunity, Innate
Type of study:
Prognostic study
/
Reviews
Topics:
Vaccines
Limits:
Animals
/
Humans
Language:
English
Journal:
Nat Biotechnol
Journal subject:
Biotechnology
Year:
2022
Document Type:
Article
Affiliation country:
S41587-021-01131-y
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