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Immune biomarkers to predict SARS-CoV-2 vaccine effectiveness in patients with hematological malignancies.
Tamariz-Amador, Luis-Esteban; Battaglia, Anna Martina; Maia, Catarina; Zherniakova, Anastasiia; Guerrero, Camila; Zabaleta, Aintzane; Burgos, Leire; Botta, Cirino; Fortuño, Maria-Antonia; Grande, Carlos; Manubens, Andrea; Arguiñano, Jose-Maria; Gomez, Clara; Perez-Persona, Ernesto; Olazabal, Iñigo; Oiartzabal, Itziar; Panizo, Carlos; Prosper, Felipe; San-Miguel, Jesus F; Rodriguez-Otero, Paula; Martín-Sánchez, Esperanza; Paiva, Bruno.
  • Tamariz-Amador LE; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain.
  • Battaglia AM; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain.
  • Maia C; Department of Experimental and Clinical Medicine, "Magna Graecia", University of Catanzaro, Catanzaro, Italy.
  • Zherniakova A; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain.
  • Guerrero C; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain.
  • Zabaleta A; Russian Research Institute of Hematology and Transfusiology, Saint-Petersburg, Russian Federation.
  • Burgos L; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain.
  • Botta C; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain.
  • Fortuño MA; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain.
  • Grande C; Department of Experimental and Clinical Medicine, "Magna Graecia", University of Catanzaro, Catanzaro, Italy.
  • Manubens A; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain.
  • Arguiñano JM; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain.
  • Gomez C; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain.
  • Perez-Persona E; Complejo Hospitalario de Navarra, IDISNA, Pamplona, Spain.
  • Olazabal I; Hospital Universitario de Galdakao, Galdakano, Spain.
  • Oiartzabal I; Hospital Universitario de Araba - sede Txagorritxu, Vitoria, Spain.
  • Panizo C; Hospital Universitario de Donostia, San Sebastian, Spain.
  • Prosper F; Hospital Universitario de Cruces, Bilbao, Spain.
  • San-Miguel JF; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain.
  • Rodriguez-Otero P; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain.
  • Martín-Sánchez E; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain.
  • Paiva B; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain.
Blood Cancer J ; 11(12): 202, 2021 12 14.
Article in English | MEDLINE | ID: covidwho-1585877
ABSTRACT
There is evidence of reduced SARS-CoV-2 vaccine effectiveness in patients with hematological malignancies. We hypothesized that tumor and treatment-related immunosuppression can be depicted in peripheral blood, and that immune profiling prior to vaccination can help predict immunogenicity. We performed a comprehensive immunological characterization of 83 hematological patients before vaccination and measured IgM, IgG, and IgA antibody response to four viral antigens at day +7 after second-dose COVID-19 vaccination using multidimensional and computational flow cytometry. Health care practitioners of similar age were the control group (n = 102). Forty-four out of 59 immune cell types were significantly altered in patients; those with monoclonal gammopathies showed greater immunosuppression than patients with B-cell disorders and Hodgkin lymphoma. Immune dysregulation emerged before treatment, peaked while on-therapy, and did not return to normalcy after stopping treatment. We identified an immunotype that was significantly associated with poor antibody response and uncovered that the frequency of neutrophils, classical monocytes, CD4, and CD8 effector memory CD127low T cells, as well as naive CD21+ and IgM+D+ memory B cells, were independently associated with immunogenicity. Thus, we provide novel immune biomarkers to predict COVID-19 vaccine effectiveness in hematological patients, which are complementary to treatment-related factors and may help tailoring possible vaccine boosters.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Biomarkers / Immunocompromised Host / Hematologic Neoplasms / COVID-19 Vaccines / COVID-19 Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Blood Cancer J Year: 2021 Document Type: Article Affiliation country: S41408-021-00594-1

Full text: Available Collection: International databases Database: MEDLINE Main subject: Biomarkers / Immunocompromised Host / Hematologic Neoplasms / COVID-19 Vaccines / COVID-19 Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Blood Cancer J Year: 2021 Document Type: Article Affiliation country: S41408-021-00594-1