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Vaccine-induced immune thrombotic thrombocytopenia.
Klok, Frederikus A; Pai, Menaka; Huisman, Menno V; Makris, Michael.
  • Klok FA; Department of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, Netherlands; Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany. Electronic address: f.a.klok@lumc.nl.
  • Pai M; Department of Medicine, McMaster University, Hamilton ON, Canada.
  • Huisman MV; Department of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, Netherlands.
  • Makris M; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK; Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK.
Lancet Haematol ; 9(1): e73-e80, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-1586163
ABSTRACT
In response to the COVID-19 pandemic, vaccines for SARS-CoV-2 were developed, tested, and introduced at a remarkable speed. Although the vaccine introduction had a major impact on the evolution of COVID-19, some potential rare side-effects of the vaccines were observed. Within a short period, three scientific groups from Norway, Germany, and the UK reported cerebral venous sinus thrombosis with thrombocytopenia and anti-platelet factor 4 (anti-PF4) antibodies in individuals following AstraZeneca-Oxford vaccination and named this new syndrome vaccine-induced immune thrombotic thrombocytopenia (VITT). This syndrome was subsequently reported in individuals who received Johnson & Johnson vaccination. In this Viewpoint, we discuss the epidemiology, pathophysiology, and optimal diagnostic and therapeutic management of VITT. Presentation of an individual with possible VITT should raise prompt testing for anti-PF4 antibodies and initiation of treatment targeting autoimmune processes with intravenous immunoglobulin and prothrombotic processes with non-heparin anticoagulation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombocytopenia / Vaccines / COVID-19 Type of study: Diagnostic study / Experimental Studies / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Lancet Haematol Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombocytopenia / Vaccines / COVID-19 Type of study: Diagnostic study / Experimental Studies / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Lancet Haematol Year: 2022 Document Type: Article