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COVID-19 and metabolic disease: mechanisms and clinical management.
Steenblock, Charlotte; Schwarz, Peter E H; Ludwig, Barbara; Linkermann, Andreas; Zimmet, Paul; Kulebyakin, Konstantin; Tkachuk, Vsevolod A; Markov, Alexander G; Lehnert, Hendrik; de Angelis, Martin Hrabe; Rietzsch, Hannes; Rodionov, Roman N; Khunti, Kamlesh; Hopkins, David; Birkenfeld, Andreas L; Boehm, Bernhard; Holt, Richard I G; Skyler, Jay S; DeVries, J Hans; Renard, Eric; Eckel, Robert H; Alberti, K George M M; Geloneze, Bruno; Chan, Juliana C; Mbanya, Jean Claude; Onyegbutulem, Henry C; Ramachandran, Ambady; Basit, Abdul; Hassanein, Mohamed; Bewick, Gavin; Spinas, Giatgen A; Beuschlein, Felix; Landgraf, Rüdiger; Rubino, Francesco; Mingrone, Geltrude; Bornstein, Stefan R.
  • Steenblock C; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Schwarz PEH; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Paul Langerhans Institute Dresden, Helmholtz Center Munich, University Hospital Carl Gustav Carus, Dresden, Germany; German Center for Diabetes Research, Neuherberg, Germany.
  • Ludwig B; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; DFG-Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany; Paul Langerhans Institute Dresden, Helmholtz Center Munich, University Hospit
  • Linkermann A; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Zimmet P; Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia.
  • Kulebyakin K; Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia; Institute for Regenerative Medicine, Medical Research and Education Centre, Lomonosov Moscow State University, Moscow, Russia.
  • Tkachuk VA; Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia; Institute for Regenerative Medicine, Medical Research and Education Centre, Lomonosov Moscow State University, Moscow, Russia.
  • Markov AG; Department of General Physiology, St Petersburg State University, St Petersburg, Russia.
  • Lehnert H; Paris Lodron University Salzburg, Salzburg, Austria.
  • de Angelis MH; German Center for Diabetes Research, Neuherberg, Germany; Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany; School of Life Sciences, Technische Universität München, Freising, Germany.
  • Rietzsch H; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Rodionov RN; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Khunti K; Diabetes Research Centre, University of Leicester, Leicester, UK.
  • Hopkins D; Department of Diabetes, School of Life Course Science and Medicine, Kings College London, London, UK.
  • Birkenfeld AL; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Department of Diabetes, School of Life Course Science and Medicine, Kings College London, London, UK; Department of Diabetology, Endocrinology and Nephrology, University Hosp
  • Boehm B; Department of Endocrinology, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
  • Holt RIG; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
  • Skyler JS; Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
  • DeVries JH; Amsterdam UMC, Internal Medicine, University of Amsterdam, Amsterdam, Netherlands; Profil Institute for Metabolic Research, Neuss, Germany.
  • Renard E; Department of Endocrinology, Diabetes, Nutrition, Montpellier University Hospital, Montpellier, France; Institute of Functional Genomics, University of Montpellier, INSERM, CNRS, Montpellier, France.
  • Eckel RH; Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Alberti KGMM; Imperial College London, London, UK.
  • Geloneze B; Obesity and Comorbidities Research Center, Universidade de Campinas, Campinas, Brazil.
  • Chan JC; Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity, Hong Kong Special Administrative Region, China; Li Ka Shing Institute of Health Science, Chinese University of Hong Kong and Prince of Wales Hospital, Hong Kong Special Administrative Region, China.
  • Mbanya JC; Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé, Yaounde, Cameroon.
  • Onyegbutulem HC; Endocrine, Diabetes and Metabolic Unit, Department of Internal Medicine, Nile University of Nigeria-Asokoro Hospital, Abuja, Nigeria.
  • Ramachandran A; India Diabetes Research Foundation, Dr A Ramachandran's Diabetes Hospitals, Chennai, India.
  • Basit A; Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, Pakistan.
  • Hassanein M; Dubai Hospital, Dubai Health Authority and Gulf Medical University, Dubai, United Arab Emirates.
  • Bewick G; Department of Diabetes, School of Life Course Science and Medicine, Kings College London, London, UK.
  • Spinas GA; Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland.
  • Beuschlein F; Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland.
  • Landgraf R; German Diabetes Foundation, Düsseldorf, Germany.
  • Rubino F; Department of Diabetes, School of Life Course Science and Medicine, Kings College London, London, UK; Bariatric and Metabolic Surgery, King's College Hospital, London, UK.
  • Mingrone G; Department of Diabetes, School of Life Course Science and Medicine, Kings College London, London, UK; Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy.
  • Bornstein SR; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Paul Langerhans Institute Dresden, Helmholtz Center Munich, University Hospital Carl Gustav Carus, Dresden, Germany; German Center for Diabetes Research, Neuherberg, Germany;
Lancet Diabetes Endocrinol ; 9(11): 786-798, 2021 11.
Article in English | MEDLINE | ID: covidwho-1586178
ABSTRACT
Up to 50% of the people who have died from COVID-19 had metabolic and vascular disorders. Notably, there are many direct links between COVID-19 and the metabolic and endocrine systems. Thus, not only are patients with metabolic dysfunction (eg, obesity, hypertension, non-alcoholic fatty liver disease, and diabetes) at an increased risk of developing severe COVID-19 but also infection with SARS-CoV-2 might lead to new-onset diabetes or aggravation of pre-existing metabolic disorders. In this Review, we provide an update on the mechanisms of how metabolic and endocrine disorders might predispose patients to develop severe COVID-19. Additionally, we update the practical recommendations and management of patients with COVID-19 and post-pandemic. Furthermore, we summarise new treatment options for patients with both COVID-19 and diabetes, and highlight current challenges in clinical management.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disease Management / COVID-19 / Metabolic Diseases Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Lancet Diabetes Endocrinol Year: 2021 Document Type: Article Affiliation country: S2213-8587(21)00244-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disease Management / COVID-19 / Metabolic Diseases Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Lancet Diabetes Endocrinol Year: 2021 Document Type: Article Affiliation country: S2213-8587(21)00244-8