Electrochemiluminescent nanostructured DNA biosensor for SARS-CoV-2 detection.
Talanta
; 240: 123203, 2022 Apr 01.
Article
in English
| MEDLINE | ID: covidwho-1586445
ABSTRACT
This work focuses on the development of an electrochemiluminescent nanostructured DNA biosensor for SARS-CoV-2 detection. Gold nanomaterials (AuNMs), specifically, a mixture of gold nanotriangles (AuNTs) and gold nanoparticles (AuNPs), are used to modified disposable electrodes that serve as an improved nanostructured electrochemiluminescent platform for DNA detection. Carbon nanodots (CDs), prepared by green chemistry, are used as coreactants agents in the [Ru(bpy)3]2+ anodic electrochemiluminescence (ECL) and the hybridization is detected by changes in the ECL signal of [Ru(bpy)3]2+/CDs in combination with AuNMs nanostructures. The biosensor is shown to detect a DNA sequence corresponding to SARS-CoV-2 with a detection limit of 514 aM.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Biosensing Techniques
/
Nanostructures
/
Metal Nanoparticles
/
COVID-19
Limits:
Humans
Language:
English
Journal:
Talanta
Year:
2022
Document Type:
Article
Affiliation country:
J.talanta.2021.123203
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