Your browser doesn't support javascript.
Prevalence and Risk Factors of Neurologic Manifestations in Hospitalized Children Diagnosed with Acute SARS-CoV-2 or MIS-C.
Fink, Ericka L; Robertson, Courtney L; Wainwright, Mark S; Roa, Juan D; Lovett, Marlina E; Stulce, Casey; Yacoub, Mais; Potera, Renee M; Zivick, Elizabeth; Holloway, Adrian; Nagpal, Ashish; Wellnitz, Kari; Czech, Theresa; Even, Katelyn M; Brunow de Carvalho, Werther; Rodriguez, Isadora Souza; Schwartz, Stephanie P; Walker, Tracie C; Campos-Miño, Santiago; Dervan, Leslie A; Geneslaw, Andrew S; Sewell, Taylor B; Pryce, Patrice; Silver, Wendy G; Lin, Jieru Egeria; Vargas, Wendy S; Topjian, Alexis; Alcamo, Alicia M; McGuire, Jennifer L; Domínguez Rojas, Jesus Angel; Muñoz, Jaime Tasayco; Hong, Sue J; Muller, William J; Doerfler, Matthew; Williams, Cydni N; Drury, Kurt; Bhagat, Dhristie; Nelson, Aaron; Price, Dana; Dapul, Heda; Santos, Laura; Kahoud, Robert; Francoeur, Conall; Appavu, Brian; Guilliams, Kristin P; Agner, Shannon C; Walson, Karen H; Rasmussen, Lindsey; Janas, Anna; Ferrazzano, Peter.
  • Fink EL; Division of Pediatric Critical Care Medicine, Department of Critical Care Medicine, Pittsburgh, Pennsylvania; Safar Center for Resuscitation Research, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: finkel@ccm.upmc.edu.
  • Robertson CL; Departments of Anesthesiology and Critical Care Medicine, and Pediatrics of The Johns Hopkins University SOM, Baltimore, Maryland.
  • Wainwright MS; Division of Pediatric Neurology, University of Washington, Seattle Children's Hospital, Seattle, Washington.
  • Roa JD; Department of Pediatrics, Universidad Nacional de Colombia and Fundación Universitaria de Ciencias de la Salud, Bogotá, Colombia.
  • Lovett ME; Division of Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio.
  • Stulce C; Department of Pediatrics, University of Chicago, Chicago, Illinois.
  • Yacoub M; Division of Critical Care, Department of Pediatrics, UMC Children's Hospital, Las Vegas, Nevada.
  • Potera RM; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Zivick E; Division of Pediatric Critical Care Medicine, Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina.
  • Holloway A; Division of Critical Care, Department of Pediatrics, University of Maryland Medical Center, Baltimore, Maryland.
  • Nagpal A; Department of Pediatrics, Section of Critical Care Medicine, Oklahoma Children's Hospital at OU health, Oklahoma University College of Medicine, Oklahoma City, Oklahoma.
  • Wellnitz K; Division of Pediatric Critical Care, Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa.
  • Czech T; Division of Pediatric Neurology, Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa.
  • Even KM; Division of Pediatric Critical Care Medicine, Penn State College of Medicine, Hershey, Pennsylvania.
  • Brunow de Carvalho W; Department of Pediatrics, University of São Paulo, São Paulo, Brazil.
  • Rodriguez IS; Department of Pediatrics, University of São Paulo, São Paulo, Brazil.
  • Schwartz SP; Department of Pediatrics, University of North Carolina at Chapel Hill Hospitals, Chapel Hill, North Carolina.
  • Walker TC; Department of Pediatrics, University of North Carolina at Chapel Hill Hospitals, Chapel Hill, North Carolina.
  • Campos-Miño S; Pediatric Intensive Care Unit, Hospital Metropolitano, Quito, Ecuador.
  • Dervan LA; Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington.
  • Geneslaw AS; Division of Pediatric Critical Care and Hospital Medicine, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York.
  • Sewell TB; Division of Pediatric Critical Care and Hospital Medicine, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York.
  • Pryce P; Division of Pediatric Critical Care and Hospital Medicine, Department of Pediatrics, Columbia University Irving Medical Center, Morgan Stanley Children's Hospital New York-Presbyterian Hospital, New York, New York.
  • Silver WG; Division of Child Neurology, Department of Neurology, Columbia University Irving Medical Center, New York, New York.
  • Lin JE; Division of Child Neurology, Department of Neurology, Columbia University Irving Medical Center, New York, New York.
  • Vargas WS; Division of Child Neurology, Department of Neurology, Columbia University Irving Medical Center, New York, New York.
  • Topjian A; Division of Critical Care Medicine at The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Departments of Anesthesiology and Critical Care Medicine and Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Alcamo AM; Division of Critical Care Medicine at The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Departments of Anesthesiology and Critical Care Medicine and Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • McGuire JL; Division of Neurology at The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Departments of Neurology and Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
  • Domínguez Rojas JA; Division of Pediatric Critical Care, Department of Pediatrics, Hospital de Emergencia Villa El Salvador, Lima, Peru.
  • Muñoz JT; Division of Pediatric Critical Care, Department of Pediatrics, Hospital de Emergencia Villa El Salvador, Lima, Peru.
  • Hong SJ; Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Muller WJ; Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Doerfler M; Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Williams CN; Division of Pediatric Critical Care, Department of Pediatrics Pediatric Critical Care and Neurotrauma Recovery Program Portland, Oregon Health & Science University, Oregon.
  • Drury K; Division of Pediatric Critical Care, Department of Pediatrics, Oregon Health & Science University, Portland, Oregon.
  • Bhagat D; Department of Neurology, NYU Langone Health, New York, New York.
  • Nelson A; Department of Neurology, NYU Langone Health, New York, New York.
  • Price D; Department of Neurology, NYU Langone Health, New York, New York.
  • Dapul H; Division of Pediatric Critical Care, Department of Pediatrics, Hassenfeld Children's Hospital at NYU Langone Health, New York, New York.
  • Santos L; Division of Pediatric Critical Care, Department of Pediatrics, Hassenfeld Children's Hospital at NYU Langone Health, New York, New York.
  • Kahoud R; Division of Pediatric Critical Care Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.
  • Francoeur C; Department of Pediatrics, CHU de Québec - Université Laval Research Center, Quebec City, Quebec, Canada.
  • Appavu B; Division of Neurology, Barrow Neurological Institute at Phoenix Children's Hospital, University of Arizona, College of Medicine, Phoenix, Arizona.
  • Guilliams KP; Departments of Neurology, Pediatrics, and Radiology, Washington University in St. Louis, St. Louis, Missouri.
  • Agner SC; Departments of Neurology, Pediatrics, and Radiology, Washington University in St. Louis, St. Louis, Missouri.
  • Walson KH; Department of Pediatric Critical Care Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia.
  • Rasmussen L; Pediatric Critical Care Medicine, Lucile Packard Children's Hospital, Stanford University, Stanford, California.
  • Janas A; Pediatric Critical Care Medicine, Lucile Packard Children's Hospital, Stanford University, Stanford, California.
  • Ferrazzano P; Department of Pediatrics, University of Wisconsin, Madison, Wisconsin.
Pediatr Neurol ; 128: 33-44, 2022 03.
Article in English | MEDLINE | ID: covidwho-1586880
ABSTRACT

BACKGROUND:

Our objective was to characterize the frequency, early impact, and risk factors for neurological manifestations in hospitalized children with acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or multisystem inflammatory syndrome in children (MIS-C).

METHODS:

Multicenter, cross-sectional study of neurological manifestations in children aged <18 years hospitalized with positive SARS-CoV-2 test or clinical diagnosis of a SARS-CoV-2-related condition between January 2020 and April 2021. Multivariable logistic regression to identify risk factors for neurological manifestations was performed.

RESULTS:

Of 1493 children, 1278 (86%) were diagnosed with acute SARS-CoV-2 and 215 (14%) with MIS-C. Overall, 44% of the cohort (40% acute SARS-CoV-2 and 66% MIS-C) had at least one neurological manifestation. The most common neurological findings in children with acute SARS-CoV-2 and MIS-C diagnosis were headache (16% and 47%) and acute encephalopathy (15% and 22%), both P < 0.05. Children with neurological manifestations were more likely to require intensive care unit (ICU) care (51% vs 22%), P < 0.001. In multivariable logistic regression, children with neurological manifestations were older (odds ratio [OR] 1.1 and 95% confidence interval [CI] 1.07 to 1.13) and more likely to have MIS-C versus acute SARS-CoV-2 (OR 2.16, 95% CI 1.45 to 3.24), pre-existing neurological and metabolic conditions (OR 3.48, 95% CI 2.37 to 5.15; and OR 1.65, 95% CI 1.04 to 2.66, respectively), and pharyngeal (OR 1.74, 95% CI 1.16 to 2.64) or abdominal pain (OR 1.43, 95% CI 1.03 to 2.00); all P < 0.05.

CONCLUSIONS:

In this multicenter study, 44% of children hospitalized with SARS-CoV-2-related conditions experienced neurological manifestations, which were associated with ICU admission and pre-existing neurological condition. Posthospital assessment for, and support of, functional impairment and neuroprotective strategies are vitally needed.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Systemic Inflammatory Response Syndrome / SARS-CoV-2 / COVID-19 / Nervous System Diseases Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: North America / South America Language: English Journal: Pediatr Neurol Journal subject: Neurology / Pediatrics Year: 2022 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Systemic Inflammatory Response Syndrome / SARS-CoV-2 / COVID-19 / Nervous System Diseases Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: North America / South America Language: English Journal: Pediatr Neurol Journal subject: Neurology / Pediatrics Year: 2022 Document Type: Article