Glial fibrillary acidic protein astrocytopathy in a patient with recent mRNA SARS-CoV-2 vaccination: COVERSHEET
Neuroimmunology Reports
; : 100053, 2021.
Article
in English
| ScienceDirect | ID: covidwho-1586941
ABSTRACT
Background Literature describing triggers of GFAP astrocytopathy (GFAP-A) is limited. We report a case of GFAP-A in a patient with recent messenger ribonucleic acid (mRNA) severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) vaccination and discuss the possible pathogenesis. Case description A 45-year-old gentleman presented with features of meningoencephalitis 31 days after the first dose and 4 days after the second dose of mRNA SARS-CoV-2 vaccination. He sequentially developed brainstem/cerebellar, autonomic and cord dysfunction. Cerebrospinal fluid was positive for GFAP autoantibody. Clinical improvement occurred after intravenous methylprednisolone and immunoglobulins. Conclusion Although we are uncertain of a causal link of GFAP-A to mRNA vaccine, indirect activation of an underlying dysregulated immune milieu is plausible.
mRNA, SARS-CoV-2, vaccine; Glial, fibrillary, acidic, protein, astrocytopathy; meningoencephalitis; myelitis; Abbreviations-, Ab-, antibody; Ag-, antigen; ALT-, alanine, transaminase; ANA-, antinuclear, antibody; AST-, aspartate, transaminase; B, -, Bacillus; C, -, Chlamydia; CT-, Computed, Tomography; DNA-, deoxyribonucleic, acid; ds-, double, stranded; GAD-, glutamic, acid, decarboxylase, HbA1c-, glycosylated, haemoglobin; HIV-, human, immunodeficiency, virus; Ig-, immunoglobulin; L-, litre; M-mycoplasma; mmol-, millimoles; MRI-, Magnetic, resonance, imaging; ng-, Nano, gram; PCR-, Polymerase, Chain, Reaction; RSV-, Respiratory, Syncytial, Virus; u-, micro; RT-, Reverse, Transcriptase; TB-, tuberculosis; U-units; umol-, micromoles; WBC-white, blood, cells
Full text:
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Collection:
Databases of international organizations
Database:
ScienceDirect
Topics:
Vaccines
Language:
English
Journal:
Neuroimmunology Reports
Year:
2021
Document Type:
Article
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