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Invasive Candida kefyr infection presenting as pyelonephritis in an ICU hospitalized COVID-19 patient: Case report and review of the literature.
Spiliopoulou, Anastasia; Kolonitsiou, Fevronia; Vrioni, Georgia; Tsoupra, Stamatia; Lekkou, Alexandra; Paliogianni, Fotini.
  • Spiliopoulou A; Department of Microbiology, University Hospital of Patras, Patras, Greece.
  • Kolonitsiou F; Department of Microbiology, University Hospital of Patras, Patras, Greece.
  • Vrioni G; Department of Microbiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Tsoupra S; Department of Internal Medicine, University Hospital of Patras, Greece.
  • Lekkou A; Department of Internal Medicine, Division of Infectious Diseases, University Hospital of Patras, Greece.
  • Paliogianni F; Department of Microbiology, University Hospital of Patras, Patras, Greece.
J Mycol Med ; 32(2): 101236, 2022 May.
Article in English | MEDLINE | ID: covidwho-1586953
ABSTRACT
Candida kefyr (Kluyveromyces marxianus), an ascomycetous environmental yeast, occasionally isolated from dairy products, represents an uncommon but emerging pathogen in immunocompromised patients. Herein, we present a case of C. kefyr pyelonephritis in a 41-year-old, previously immunocompetent, patient who was hospitalized in an COVID-19 ICU. Pyelonephritis was associated with caliectasis and obstruction due to possible fungus ball formation. Predisposing factors included ICU stay, use of broad spectrum antibiotics and steroids, central venous catheterization, mechanical ventilation and urologic manipulation. Susceptibility testing revealed high MIC values to amphotericin B. Infection was effectively controlled by prolonged administration of fluconazole without further surgical intervention. COVID-19 complicated with invasive candidiasis is an increasingly observed clinical situation that warrants high suspicion index and careful evaluation of laboratory data.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pyelonephritis / Candidiasis, Invasive / COVID-19 Type of study: Case report / Diagnostic study / Etiology study / Experimental Studies / Prognostic study Topics: Long Covid Limits: Adult / Humans Language: English Journal: J Mycol Med Year: 2022 Document Type: Article Affiliation country: J.mycmed.2021.101236

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pyelonephritis / Candidiasis, Invasive / COVID-19 Type of study: Case report / Diagnostic study / Etiology study / Experimental Studies / Prognostic study Topics: Long Covid Limits: Adult / Humans Language: English Journal: J Mycol Med Year: 2022 Document Type: Article Affiliation country: J.mycmed.2021.101236