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Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates.
Stammes, Marieke A; Lee, Ji Hyun; Meijer, Lisette; Naninck, Thibaut; Doyle-Meyers, Lara A; White, Alexander G; Borish, H Jacob; Hartman, Amy L; Alvarez, Xavier; Ganatra, Shashank; Kaushal, Deepak; Bohm, Rudolf P; le Grand, Roger; Scanga, Charles A; Langermans, Jan A M; Bontrop, Ronald E; Finch, Courtney L; Flynn, JoAnne L; Calcagno, Claudia; Crozier, Ian; Kuhn, Jens H.
  • Stammes MA; Biomedical Primate Research Centre (BPRC), 2288 GJ, Rijswijk, The Netherlands. Electronic address: stammes@bprc.nl.
  • Lee JH; Integrated Research Facility at Fort Detrick (IRF-Frederick), Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Fort Detrick, Frederick, MD 21702, USA.
  • Meijer L; Biomedical Primate Research Centre (BPRC), 2288 GJ, Rijswijk, The Netherlands.
  • Naninck T; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, Inserm, CEA, 92260 Fontenay-aux-Roses, France.
  • Doyle-Meyers LA; Tulane National Primate Research Center, Covington, LA 70433, USA; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
  • White AG; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
  • Borish HJ; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
  • Hartman AL; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pitt Public Health, Pittsburgh, PA 15261, USA.
  • Alvarez X; Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
  • Ganatra S; Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
  • Kaushal D; Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
  • Bohm RP; Tulane National Primate Research Center, Covington, LA 70433, USA; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
  • le Grand R; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, Inserm, CEA, 92260 Fontenay-aux-Roses, France.
  • Scanga CA; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
  • Langermans JAM; Biomedical Primate Research Centre (BPRC), 2288 GJ, Rijswijk, The Netherlands; Department Population Health Sciences, Division of Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, 3584 CL, Utrecht, The Netherlands.
  • Bontrop RE; Biomedical Primate Research Centre (BPRC), 2288 GJ, Rijswijk, The Netherlands; Department of Biology, Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH, Utrecht, The Netherlands.
  • Finch CL; Integrated Research Facility at Fort Detrick (IRF-Frederick), Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Fort Detrick, Frederick, MD 21702, USA.
  • Flynn JL; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
  • Calcagno C; Integrated Research Facility at Fort Detrick (IRF-Frederick), Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Fort Detrick, Frederick, MD 21702, USA.
  • Crozier I; Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
  • Kuhn JH; Integrated Research Facility at Fort Detrick (IRF-Frederick), Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Fort Detrick, Frederick, MD 21702, USA.
Trends Mol Med ; 28(2): 123-142, 2022 02.
Article in English | MEDLINE | ID: covidwho-1586964
ABSTRACT
Chest X-ray (CXR), computed tomography (CT), and positron emission tomography-computed tomography (PET-CT) are noninvasive imaging techniques widely used in human and veterinary pulmonary research and medicine. These techniques have recently been applied in studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-exposed non-human primates (NHPs) to complement virological assessments with meaningful translational readouts of lung disease. Our review of the literature indicates that medical imaging of SARS-CoV-2-exposed NHPs enables high-resolution qualitative and quantitative characterization of disease otherwise clinically invisible and potentially provides user-independent and unbiased evaluation of medical countermeasures (MCMs). However, we also found high variability in image acquisition and analysis protocols among studies. These findings uncover an urgent need to improve standardization and ensure direct comparability across studies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study / Qualitative research Limits: Animals / Humans Language: English Journal: Trends Mol Med Journal subject: Molecular Biology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study / Qualitative research Limits: Animals / Humans Language: English Journal: Trends Mol Med Journal subject: Molecular Biology Year: 2022 Document Type: Article