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Impact of serum lactate dehydrogenase on the short-term prognosis of COVID-19 with pre-existing cardiovascular diseases.
Masumoto, Akiko; Kitai, Takeshi; Matsumoto, Shingo; Kuroda, Shunsuke; Kohsaka, Shun; Tachikawa, Ryo; Seo, Ryutaro; Doi, Asako; Tomii, Keisuke; Yonetsu, Taishi; Torii, Sho; Komuro, Issei; Hirata, Ken-Ichi; Node, Koichi; Matsue, Yuya; Furukawa, Yutaka.
  • Masumoto A; Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan; Division of Cardiovascular Medicine, Hyogo Brain and Heart Center, Himeji, Japan.
  • Kitai T; Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan; Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Medicine Center, 6-1 Kishibe-shinmachi, Osaka, Japan. Electronic address: t-kitai@kcho.jp.
  • Matsumoto S; Department of Cardiovascular Medicine, Department of Internal Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
  • Kuroda S; Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, United States.
  • Kohsaka S; Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
  • Tachikawa R; Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
  • Seo R; Department of Intensive Care, Kobe City Medical Center General Hospital, Kobe, Japan.
  • Doi A; Department of Infectious Diseases, Kobe City Medical Center General Hospital, Kobe, Japan.
  • Tomii K; Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
  • Yonetsu T; Department of Interventional Cardiology, Tokyo Medical and Dental University, Tokyo, Japan.
  • Torii S; Department of Cardiology, Tokai University School of Medicine, Isehara, Japan.
  • Komuro I; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Hirata KI; Department of Internal Medicine, Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Node K; Department of Cardiovascular Medicine, Saga University, Saga, Japan.
  • Matsue Y; Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Furukawa Y; Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
J Cardiol ; 79(4): 501-508, 2022 04.
Article in English | MEDLINE | ID: covidwho-1587218
ABSTRACT

BACKGROUND:

Patients with coronavirus disease 2019 (COVID-19) and underlying cardiovascular comorbidities have poor prognoses. Our aim was to identify the impact of serum lactate dehydrogenase (LDH), which is associated with mortality in acute respiratory distress syndrome, on the prognoses of patients with COVID-19 and underlying cardiovascular comorbidities.

METHODS:

Among 1518 patients hospitalized with COVID-19 enrolled in the CLAVIS-COVID (Clinical Outcomes of COVID-19 Infection in Hospitalized Patients with Cardiovascular Diseases and/or Risk Factors study), 515 patients with cardiovascular comorbidities were analyzed. Patients were divided into tertiles based on LDH levels at admission [tertile 1 (T1), <235 U/L; tertile 2 (T2), 235-355 U/L; and tertile 3 (T3); ≥356 U/L]. We investigated the impact of LDH levels on the in-hospital mortality.

RESULTS:

The mean age was 70.4 ± 30.0 years, and 65.3% were male. There were significantly more in-hospital deaths in T3 than in T1 and T2 [n = 50 (29.2%) vs. n = 15 (8.7%), and n = 24 (14.0%), respectively; p < 0.001]. Multivariable analysis adjusted for age, comorbidities, vital signs, and laboratory data including D-dimer and high-sensitivity troponin showed T3 was associated with an increased risk of in-hospital mortality (adjusted hazard ratio, 3.04; 95% confidence interval, 1.50-6.13; p = 0.002).

CONCLUSIONS:

High serum LDH levels at the time of admission are associated with an increased risk of in-hospital death in patients with COVID-19 and known cardiovascular disease and may aid in triage of these patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Humans / Male / Middle aged Language: English Journal: J Cardiol Journal subject: Cardiology Year: 2022 Document Type: Article Affiliation country: J.jjcc.2021.12.014

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Humans / Male / Middle aged Language: English Journal: J Cardiol Journal subject: Cardiology Year: 2022 Document Type: Article Affiliation country: J.jjcc.2021.12.014