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Interrupted time-series analysis showed unintended consequences of non-pharmaceutical interventions on pediatric hospital admissions.
Moore, Hannah C; Le, Huong; Mace, Ariel; Blyth, Christopher C; Yeoh, Daniel; Foley, David; Martin, Andrew.
  • Moore HC; Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, Australia. Electronic address: Hannah.Moore@telethonkids.org.au.
  • Le H; Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, Australia.
  • Mace A; Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, Australia; Department of General Paediatrics, Perth Children's Hospital, Perth, Australia; Department of Paediatrics, Fiona Stanley Hospital, Murdoch, Australia.
  • Blyth CC; Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, Australia; Department of Infectious Diseases, Perth Children's Hospital, Perth, Australia; PathWest Laboratory Medicine, Perth, Australia; School of Medicine, University of Wester
  • Yeoh D; Department of Infectious Diseases, Perth Children's Hospital, Perth, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria.
  • Foley D; Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, Australia; PathWest Laboratory Medicine, Perth, Australia.
  • Martin A; Department of General Paediatrics, Perth Children's Hospital, Perth, Australia.
J Clin Epidemiol ; 143: 1-10, 2022 03.
Article in English | MEDLINE | ID: covidwho-1587328
ABSTRACT

OBJECTIVE:

COVID-19-associated non-pharmaceutical interventions (NPI) have disrupted respiratory viral transmission. We quantified the changes in pediatric hospital admissions in 2020 from five different NPI phases in Western Australia for acute lower respiratory infections (ALRI) in children in the context of all-cause admissions. STUDY DESIGN AND

SETTING:

We assessed anonymised hospitalization data from Perth Children's Hospital (Jan 2015-Dec 2020) for all-cause admissions, ALRI, febrile illnesses and trauma (negative control) in those <17 years. We evaluated absolute changes in admissions and the weekly change estimated from interrupted time-series models.

RESULTS:

The absolute number of admissions was comparable in 2020 (15,678) vs. 2015 to 2019 average (15,310). Following the introduction of strict NPIs, all-cause admissions declined by 35%, recovered to pre-pandemic levels, then increased by 24% following NPI cessation. ALRI admissions in children <5 years initially declined by 89%, which was sustained throughout the gradual easing of NPI until an increase of 579% (997% in <3 months) following the final easing of NPI. Admissions for trauma showed minimal changes in 2020 compared to preceding years.

CONCLUSION:

COVID-19-associated NPI had significant unintended consequences in health service utilization, especially for ALRI and infants <3 months, prompting the need to understand viral transmission dynamics in young children.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / COVID-19 Type of study: Experimental Studies / Observational study Limits: Child / Child, preschool / Humans / Infant Language: English Journal: J Clin Epidemiol Journal subject: Epidemiology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / COVID-19 Type of study: Experimental Studies / Observational study Limits: Child / Child, preschool / Humans / Infant Language: English Journal: J Clin Epidemiol Journal subject: Epidemiology Year: 2022 Document Type: Article