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Leukocytoclastic vasculitis (cutaneous small-vessel vasculitis) after COVID-19 vaccination.
Fiorillo, G; Pancetti, S; Cortese, A; Toso, F; Manara, S; Costanzo, A; Borroni, R G.
  • Fiorillo G; Dermatology Unit, Humanitas Research Hospital - IRCCS, Rozzano, MI, Italy; Humanitas University, Pieve Emanuele, MI, Italy. Electronic address: giovanni.fiorillo@humanitas.it.
  • Pancetti S; Humanitas University, Pieve Emanuele, MI, Italy; Pathology Unit, Humanitas Research Hospital - IRCCS, Rozzano, MI, Italy.
  • Cortese A; Dermatology Unit, Humanitas Research Hospital - IRCCS, Rozzano, MI, Italy; Humanitas University, Pieve Emanuele, MI, Italy.
  • Toso F; Dermatology Unit, Humanitas Research Hospital - IRCCS, Rozzano, MI, Italy; Humanitas University, Pieve Emanuele, MI, Italy.
  • Manara S; Pathology Unit, Humanitas Research Hospital - IRCCS, Rozzano, MI, Italy.
  • Costanzo A; Dermatology Unit, Humanitas Research Hospital - IRCCS, Rozzano, MI, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy.
  • Borroni RG; Dermatology Unit, Humanitas Research Hospital - IRCCS, Rozzano, MI, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy.
J Autoimmun ; 127: 102783, 2022 02.
Article in English | MEDLINE | ID: covidwho-1587360
ABSTRACT
Vaccinations may induce cutaneous adverse events, due to nonspecific inflammation or immuno-mediated reactions. Several types of vasculitis have been observed. We report on a 71-year-old woman who developed cutaneous small-vessel vasculitis after the second dose of Vaxzevria COVID-19 vaccination, showing leukocytoclastic vasculitis on histopathological examination of a skin biopsy. Cutaneous small-vessel vasculitis is a rare condition which can be idiopathic or secondary to underlying infections, connective tissue disorders, malignancy, and medications. The pathogenesis involves immune complex deposition in small blood vessels, leading to activation of the complement system and recruitment of leukocytes. Exacerbation of small-vessel vasculitis has been reported following the administration of various vaccines, particularly influenza vaccine. It is expected that SARS-CoV-2 vaccine results in the activation of B- and T-cells and antibody formation. We hypothesize that leukocytoclastic vasculitis caused by immune complex deposition within cutaneous small vessels could be a rare side effect of Vaxzevria COVID-19 vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vasculitis, Leukocytoclastic, Cutaneous / COVID-19 Vaccines Type of study: Case report Topics: Vaccines Limits: Aged / Female / Humans Language: English Journal: J Autoimmun Journal subject: Allergy and Immunology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vasculitis, Leukocytoclastic, Cutaneous / COVID-19 Vaccines Type of study: Case report Topics: Vaccines Limits: Aged / Female / Humans Language: English Journal: J Autoimmun Journal subject: Allergy and Immunology Year: 2022 Document Type: Article