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Low transferrin levels predict heightened inflammation in patients with COVID-19: New insights.
Claise, Catherine; Saleh, Jumana; Rezek, Marwa; Vaulont, Sophie; Peyssonnaux, Carole; Edeas, Marvin.
  • Claise C; Groupe Hospitalier Sud Ile-de-France (GHSIF), Melun, France.
  • Saleh J; College of Medicine, Sultan Qaboos University, Muscat, Oman.
  • Rezek M; Groupe Hospitalier Sud Ile-de-France (GHSIF), Melun, France.
  • Vaulont S; Université de Paris, INSERM U1016, Institut Cochin, CNRS UMR 8104, Paris, France; Laboratory of Excellence GR-Ex, Paris, France.
  • Peyssonnaux C; Université de Paris, INSERM U1016, Institut Cochin, CNRS UMR 8104, Paris, France; Laboratory of Excellence GR-Ex, Paris, France.
  • Edeas M; Université de Paris, INSERM U1016, Institut Cochin, CNRS UMR 8104, Paris, France; Laboratory of Excellence GR-Ex, Paris, France. Electronic address: marvin.edeas@inserm.fr.
Int J Infect Dis ; 116: 74-79, 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1587623
ABSTRACT

OBJECTIVES:

Mounting evidence links hyperinflammation in gravely ill patients to low serum iron levels and hyperferritinemia. However, little attention has been paid to other iron-associated markers such as transferrin. The aim of this study was to investigate the association of different iron parameters in severe COVID-19 and their relation to disease severity. SUBJECTS AND

METHODS:

This study involved 73 hospitalized patients with positive test results for SARS-CoV-2. Patients were classified into two groups according to symptom severity mild and severe. Blood levels of anti-SARS-CoV-2 antibodies, interleukin 6 (IL-6), C-reactive protein (CRP), and iron-related biomarkers were measured.

RESULTS:

The results revealed a significant increase in IL-6, CRP, and ferritin levels and decreased transferrin and iron levels in severe COVID-19. Transferrin negatively predicted variations in IgM and IgG levels (P < 0.001), as well as 34.4% and 36.6% increase in IL-6 and CRP levels, respectively (P < 0.005). Importantly, transferrin was the main negative predictor of ferritin levels, determining 22.7% of serum variations (P < 0.001).

CONCLUSION:

Reduced serum transferrin and iron levels, along with the increased CRP and high ferritin, were strongly associated with the heightened inflammatory and immune state in COVID-19. Transferrin can be used as a valuable predictor of increased severity and progression of the disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Transferrin / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.ijid.2021.12.340

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Transferrin / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.ijid.2021.12.340