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Role of immune mediators in predicting hospitalization of SARS-CoV-2 positive patients.
Ashrafzadeh-Kian, S; Campbell, M R; Jara Aguirre, J C; Walsh, J; Kumanovics, A; Jenkinson, G; Rinaldo, P; Snyder, M R; Algeciras-Schimnich, A.
  • Ashrafzadeh-Kian S; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Campbell MR; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Jara Aguirre JC; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Division of Pathology and Laboratory Medicine, Children's National Hospital, Washington, DC, USA.
  • Walsh J; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
  • Kumanovics A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Jenkinson G; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
  • Rinaldo P; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Snyder MR; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Algeciras-Schimnich A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: Algeciras.Alicia@mayo.edu.
Cytokine ; 150: 155790, 2022 02.
Article in English | MEDLINE | ID: covidwho-1587975
ABSTRACT

BACKGROUND:

Several immune mediators (IM) including cytokines, chemokines, and their receptors have been suggested to play a role in COVID-19 pathophysiology and severity.

AIM:

To determine if early IM profiles are predictive of clinical outcome and which of the IMs tested possess the most clinical utility.

METHODS:

A custom bead-based multiplex assay was used to measure IM concentrations in a cohort of SARS-CoV-2 PCR positive patients (n = 326) with varying disease severities as determined by hospitalization status, length of hospital stay, and survival. Patient groups were compared, and clinical utility was assessed. Correlation plots were constructed to determine if significant relationships exist between the IMs in the setting of COVID-19.

RESULTS:

In PCR positive SARS-CoV-2 patients, IL-6 was the best predictor of the need for hospitalization and length of stay. Additionally, MCP-1 and sIL-2Rα were moderate predictors of the need for hospitalization. Hospitalized PCR positive SARS-CoV-2 patients displayed a notable correlation between sIL-2Rα and IL-18 (Spearman's ρ = 0.48, P=<0.0001).

CONCLUSIONS:

IM profiles between non-hospitalized and hospitalized patients were distinct. IL-6 was the best predictor of COVID-19 severity among all the IMs tested.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokines / Receptors, Cytokine / SARS-CoV-2 / COVID-19 / Hospitalization Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Cytokine Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: J.cyto.2021.155790

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokines / Receptors, Cytokine / SARS-CoV-2 / COVID-19 / Hospitalization Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Cytokine Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: J.cyto.2021.155790