Mitochondrial nicotinic acetylcholine receptors: Mechanisms of functioning and biological significance.
Int J Biochem Cell Biol
; 143: 106138, 2022 02.
Article
in English
| MEDLINE | ID: covidwho-1588223
ABSTRACT
Nicotinic acetylcholine receptors mediate fast synaptic transmission in neuro-muscular junctions and autonomic ganglia and modulate survival, proliferation and neurotransmitter or cytokine release in the brain and non-excitable cells. The neuronal-type nicotinic acetylcholine receptors are expressed in the outer mitochondria membrane to regulate the release of pro-apoptotic substances like cytochrome c or reactive oxygen species. In the intracellular environment, nicotinic acetylcholine receptor signaling is ion-independent and triggers intramitochondrial kinases, similar to those activated by plasma membrane nicotinic acetylcholine receptors. The present review will describe the data obtained during the last five years including, in particular, post-translational glycosylation as a targeting signal to mitochondria, mechanisms of mitochondrial nicotinic acetylcholine receptor signaling studied with subtype-specific agonists, antagonists, positive allosteric modulators and knockout mice lacking certain nicotinic acetylcholine receptor subunits, interaction of mitochondrial nicotinic acetylcholine receptors with Bcl-2 family proteins and their involvement in important pathologies like neuroinflammation, liver damage and SARS-CoV-2 infection.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Receptors, Nicotinic
/
Proto-Oncogene Proteins c-bcl-2
/
Chemical and Drug Induced Liver Injury
/
COVID-19
/
Neuroinflammatory Diseases
/
Mitochondria
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Int J Biochem Cell Biol
Journal subject:
Biochemistry
Year:
2022
Document Type:
Article
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