ChAdOx1 vaccination, blood coagulation, and inflammation: No effect on coagulation but increased interleukin-6.
Res Pract Thromb Haemost
; 5(8): e12630, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1588882
ABSTRACT
BACKGROUND:
Vaccination is the leading approach in combatting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. ChAdOx1 nCoV-19 vaccination (ChAdOx1) has been linked to a higher frequency of rare thrombosis and thromboembolism. This study aimed to explore markers related to the blood coagulation system activation and inflammation, before and after ChAdOx1 vaccination. PATIENTS ANDMETHODS:
An observational cohort study including 40 health care workers. Whole blood samples were collected before, and either 1 or 2 days after vaccination. Activated coagulation factors in complex with their natural inhibitors were determined by custom ELISAs, including thrombinantithrombin (TAT), kallikreinC1-esterase-inhibitor (PKaC1Inh), factor(F)IXaAT, FXaAT, FXIaAT, FXIaalpha-1-antitrypsin (α1AT), FXIaC1inh, and FVIIaAT. Plasma concentrations of interleukin (IL)-6 and IL-18 were quantified via ELISA. Analyses were performed using Wilcoxon signed-rank test.RESULTS:
Levels of FVIIaAT decreased with a median (IQR) of 707 (549-1028) pg/ml versus 598 (471-996) pg/ml, p = 0.01; and levels of IL-6 increased, 4.0 (1.9-6.8) pg/ml versus 6.9 (3.6-12.2) pg/ml, p = 0.02, after vaccination. No changes were observed in TAT, PKaC1Inh, FIXaAT, FXaAT, FXIaAT, FXIaα1AT, FXIaC1inh, and IL-18.CONCLUSION:
ChAdOx1 leads to an inflammatory response with increased levels of IL-6. We did not observe activation of the blood coagulation system 1-2 days following vaccination.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Vaccines
Language:
English
Journal:
Res Pract Thromb Haemost
Year:
2021
Document Type:
Article
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