Relationship between Antibody Levels and SARS-Cov-2 Reinfection
Annals of Clinical & Laboratory Science
; 51(6):750-755, 2021.
Article
in English
| MEDLINE | ID: covidwho-1589601
ABSTRACT
OBJECTIVE:
In this period when mutant strains are increasing all over the world, studies on how much humoral immunity will protect against the Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) are quite limited. The aim of our study is to investigate the positivity and antibody levels of the COVID-19 reverse transcription polymerase chain reaction (RT-PCR) test, the frequency of SARS-CoV-2 re-infection, and the protective antibody level against re-infection.METHODS:
Patients who were positive for COVID-19 IgG antibody between 1 July and 31 August were included in our study. The COVID-19 RT-PCR test positivity, age, gender and comorbidities of these patients were recorded before this date. The COVID-19 RT-PCR test positivity of these patients was followed from the National COVID-19 Database between September 1, 2020 and February 28, 2021.RESULTS:
1665 patients (female male 683 982, mean age 40.6+/-13.4 years). Among all patients, 14 patients had reinfection and the frequency of reinfection was 0.8%. It was observed that the frequency of reinfection was more frequent in patients with PCR negative (p<0.001). The IgG cut-off value causing reinfection was found to be 11.9 (AUC 0.844, 79.2% sensitivity, 78.6% specificity) (p<0.001).CONCLUSION:
Humoral antibodies against SARS-CoV-2 were protective against COVID-19 reinfection, 0.8% of the patients had reinfection and the resultant reinfection was mostly seen in PCR negative patients who were asymptomatic.
Adult; Antibodies, Viral; *COVID-19/im, [Immunology]; COVID-19/pc, [Prevention, &, Control]; COVID-19, Serological, Testing/mt, [Methods]; Diagnostic, Tests, Routine; Female; Humans; Immunity, Humoral/im, [Immunology]; Immunoglobulin, G/an, [Analysis]; Immunoglobulin, G/im, [Immunology]; Male; Middle, Aged; *Reinfection/im, [Immunology]; *SARS-CoV-2/im, [Immunology]; SARS-CoV-2/py, [Pathogenicity]; 0, (Antibodies, Viral); 0, (Immunoglobulin, G)
Search on Google
Collection:
Databases of international organizations
Database:
MEDLINE
Language:
English
Journal:
Annals of Clinical & Laboratory Science
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS