Immunopathology of RSV: An Updated Review.

Bergeron, Harrison C; Tripp, Ralph A

Bergeron, Harrison C; Tripp, Ralph A.

Bergeron HC; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Tripp RA; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

Viruses ; 13(12)2021 12 10.

Article in English | MEDLINE | ID: covidwho-1591709

ABSTRACT

ABSTRACT

RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding of virus-host interactions and immunity contribute to the lack of biological countermeasures. This review updates the current understanding of RSV immunity and immunopathology with a focus on interferon responses, animal modeling, and correlates of protection.

Subject(s)

Respiratory Syncytial Virus Infections/immunology; Respiratory Syncytial Virus Infections/virology; Respiratory Syncytial Virus, Human/immunology; Adaptive Immunity; Animals; Disease Models, Animal; Humans; Immunity, Innate; Interferons/immunology; Interferons/metabolism; Respiratory Syncytial Virus Infections/epidemiology; Respiratory Syncytial Virus Infections/prevention & control; Respiratory Syncytial Virus Vaccines/immunology; Respiratory Syncytial Virus, Human/physiology

Keywords

RSV; hostpathogen interaction; immunity; immunopathology; respiratory syncytial virus

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Syncytial Virus, Human / Respiratory Syncytial Virus Infections Type of study: Observational study Topics: Vaccines Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: V13122478

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