Recombinant Adjuvanted Zoster Vaccine and Reduced Risk of Coronavirus Disease 2019 Diagnosis and Hospitalization in Older Adults.
J Infect Dis
; 225(11): 1915-1922, 2022 06 01.
Article
in English
| MEDLINE | ID: covidwho-1708333
ABSTRACT
BACKGROUND:
Some vaccines elicit nonspecific immune responses that may protect against heterologous infections. We evaluated the association between recombinant adjuvanted zoster vaccine (RZV) and coronavirus disease 2019 (COVID-19) outcomes at Kaiser Permanente Southern California.METHODS:
In a cohort design, adults aged ≥50 years who received ≥1 RZV dose before 1 March 2020 were matched 12 to unvaccinated individuals and followed until 31 December 2020. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for COVID-19 outcomes were estimated using Cox proportional hazards regression. In a test-negative design, cases had a positive severe acute respiratory syndrome coronavirus 2 test and controls had only negative tests, during 1 March-31 December 2020. Adjusted odds ratios (aORs) and 95% CIs for RZV receipt were estimated using logistic regression.RESULTS:
In the cohort design, 149â 244 RZV recipients were matched to 298â 488 unvaccinated individuals. The aHRs for COVID-19 diagnosis and hospitalization were 0.84 (95% CI, .81-.87) and 0.68 (95% CI, .64-.74), respectively. In the test-negative design, 8.4% of 75â 726 test-positive cases and 13.1% of 340â 898 test-negative controls had received ≥1 RZV dose (aOR, 0.84 [95% CI, .81-.86]).CONCLUSIONS:
RZV vaccination was associated with a 16% lower risk of COVID-19 diagnosis and 32% lower risk of hospitalization. Further study of vaccine-induced nonspecific immunity for potential attenuation of future pandemics is warranted.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Herpes Zoster Vaccine
/
COVID-19
/
Herpes Zoster
Type of study:
Cohort study
/
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Aged
/
Humans
Language:
English
Journal:
J Infect Dis
Year:
2022
Document Type:
Article
Affiliation country:
Infdis
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