Potential role of viral infections in miscarriage and insights into the underlying molecular mechanisms.
Congenit Anom (Kyoto)
; 62(2): 54-67, 2022 Mar.
Article
in English
| MEDLINE | ID: covidwho-1594077
ABSTRACT
Intrauterine viruses can infect the decidua and placenta and cause adverse effects on the fetus during gestation. This review discusses the contribution of various viral infections to miscarriage and the molecular mechanisms by which viruses can cause devastating effects on healthy fetuses and induce miscarriage. Severe acute respiratory syndrome coronavirus 2 as newly emerged coronavirus was considered here, due to the concerns about its role during pregnancy and inducing miscarriage, as well. In this narrative review, an extensive literature search was conducted to find all studies investigating viral infections in miscarriage and their molecular mechanisms published over the past 20 years. The results of various studies investigating the roles of 20 viral infections in miscarriage are presented. Then, the mechanisms of pregnancy loss in viral infections were addressed, including alteration of trophoblast invasion and placental dysfunction, inducing excessive maternal immune response, and inducing apoptosis in the placental tissue. Viruses may cause pregnancy loss through different mechanisms and our knowledge about these mechanisms can be helpful for controlling or preventing viral infections and achieving a successful pregnancy.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pregnancy Complications, Infectious
/
Virus Diseases
/
Abortion, Spontaneous
/
COVID-19
Type of study:
Reviews
Topics:
Long Covid
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Congenit Anom (Kyoto)
Journal subject:
Teratology
Year:
2022
Document Type:
Article
Affiliation country:
Cga.12458
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