Your browser doesn't support javascript.
Innate Receptors Expression by Lung Nociceptors: Impact on COVID-19 and Aging.
Hiroki, Carlos H; Sarden, Nicole; Hassanabad, Mortaza F; Yipp, Bryan G.
  • Hiroki CH; Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Sarden N; Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Hassanabad MF; Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Yipp BG; Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Front Immunol ; 12: 785355, 2021.
Article in English | MEDLINE | ID: covidwho-1594099
ABSTRACT
The lungs are constantly exposed to non-sterile air which carries harmful threats, such as particles and pathogens. Nonetheless, this organ is equipped with fast and efficient mechanisms to eliminate these threats from the airways as well as prevent pathogen invasion. The respiratory tract is densely innervated by sensory neurons, also known as nociceptors, which are responsible for the detection of external stimuli and initiation of physiological and immunological responses. Furthermore, expression of functional innate receptors by nociceptors have been reported; however, the influence of these receptors to the lung function and local immune response is poorly described. The COVID-19 pandemic has shown the importance of coordinated and competent pulmonary immunity for the prevention of pathogen spread as well as prevention of excessive tissue injury. New findings suggest that lung nociceptors can be a target of SARS-CoV-2 infection; what remains unclear is whether innate receptor trigger sensory neuron activation during SARS-CoV-2 infection and what is the relevance for the outcomes. Moreover, elderly individuals often present with respiratory, neurological and immunological dysfunction. Whether aging in the context of sensory nerve function and innate receptors contributes to the disorders of these systems is currently unknown. Here we discuss the expression of innate receptors by nociceptors, particularly in the lungs, and the possible impact of their activation on pulmonary immunity. We then demonstrate recent evidence that suggests lung sensory neurons as reservoirs for SARS-CoV-2 and possible viral recognition via innate receptors. Lastly, we explore the mechanisms by which lung nociceptors might contribute to disturbance in respiratory and immunological responses during the aging process.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Nociceptors / Aging / Transient Receptor Potential Channels / SARS-CoV-2 / COVID-19 / Immunity, Innate / Lung Limits: Aged / Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.785355

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Nociceptors / Aging / Transient Receptor Potential Channels / SARS-CoV-2 / COVID-19 / Immunity, Innate / Lung Limits: Aged / Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.785355