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Frequency, Characteristics and Complications of COVID-19 in Hospitalized Infants.
Hobbs, Charlotte V; Woodworth, Kate; Young, Cameron C; Jackson, Ashley M; Newhams, Margaret M; Dapul, Heda; Maamari, Mia; Hall, Mark W; Maddux, Aline B; Singh, Aalok R; Schuster, Jennifer E; Rowan, Courtney M; Fitzgerald, Julie C; Irby, Katherine; Kong, Michele; Mack, Elizabeth H; Staat, Mary A; Cvijanovich, Natalie Z; Bembea, Melania M; Coates, Bria M; Halasa, Natasha B; Walker, Tracie C; McLaughlin, Gwenn E; Babbitt, Christopher J; Nofziger, Ryan A; Loftis, Laura L; Bradford, Tamara T; Campbell, Angela P; Patel, Manish M; Randolph, Adrienne G.
  • Hobbs CV; From the Department of Pediatrics, Division of Disease, Microbiology, University of Mississippi Medical Center, Jackson, Mississippi.
  • Woodworth K; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Young CC; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts.
  • Jackson AM; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Newhams MM; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts.
  • Dapul H; Department of Pediatrics, Division of Infectious Diseases, New York University Grossman School of Medicine and Hassenfeld Children's Hospital, New York, New York.
  • Maamari M; Department of Pediatrics, Division of Critical Care Medicine, University of Texas Southwestern, Children's Medical Center Dallas, Texas.
  • Hall MW; Division of Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH.
  • Maddux AB; Department of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado.
  • Singh AR; Pediatric Critical Care Division, Maria Fareri Children's Hospital at Westchester Medical Center and New York Medical College, Valhalla, New York.
  • Schuster JE; Division of Pediatric Infectious Disease, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri.
  • Rowan CM; Division of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, Indiana.
  • Fitzgerald JC; Division of Critical Care, Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Irby K; Section of Pediatric Critical Care, Department of Pediatrics, Arkansas Children's Hospital, Little Rock, Arkansas.
  • Kong M; Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama.
  • Mack EH; Division of Pediatric Critical Care Medicine, Medical University of South Carolina, Charleston, South Carolina.
  • Staat MA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
  • Cvijanovich NZ; Division of Critical Care Medicine, UCSF Benioff Children's Hospital Oakland, California.
  • Bembea MM; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • Coates BM; Division of Pediatric Critical Care Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Halasa NB; Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Walker TC; Department of Pediatrics, Division of Critical Care, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • McLaughlin GE; Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida.
  • Babbitt CJ; Division of Pediatric Critical Care, Department of Pediatrics, Miller Children's and Women's Hospital of Long Beach, Long Beach, California.
  • Nofziger RA; Division of Critical Care Medicine, Akron Children's Hospital, Akron, Ohio.
  • Loftis LL; Section of Critical Care Medicine, Department of Pediatrics, Texas Children's Hospital, Houston, Texas.
  • Bradford TT; Department of Pediatrics, Division of Cardiology, Louisiana State University Health Sciences Center and Children's Hospital of New Orleans, New Orleans, Louisiana.
  • Campbell AP; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Patel MM; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Randolph AG; Department of Pediatrics, Division of Infectious Diseases, New York University Grossman School of Medicine and Hassenfeld Children's Hospital, New York, New York.
Pediatr Infect Dis J ; 41(3): e81-e86, 2022 03 01.
Article in English | MEDLINE | ID: covidwho-1594109
ABSTRACT

BACKGROUND:

Previous studies of severe acute respiratory syndrome coronavirus 2 infection in infants have incompletely characterized factors associated with severe illness or focused on infants born to mothers with coronavirus disease 2019 (COVID-19). Here we highlight demographics, clinical characteristics and laboratory values that differ between infants with and without severe acute COVID-19.

METHODS:

Active surveillance was performed by the Overcoming COVID-19 network to identify children and adolescents with severe acute respiratory syndrome coronavirus 2-related illness hospitalized at 62 sites in 31 states from March 15 to December 27, 2020. We analyzed patients >7 days to <1 year old hospitalized with symptomatic acute COVID-19.

RESULTS:

We report 232 infants >7 days to <1 year of age hospitalized with acute symptomatic COVID-19 from 37 US hospitals in our cohort from March 15 to December 27, 2020. Among 630 cases of severe COVID-19 in patients >7 days to <18 years old, 128 (20.3%) were infants. In infants with severe illness from the entire study period, the median age was 2 months, 66% were from racial and ethnic minority groups, 66% were previously healthy, 73% had respiratory complications, 13% received mechanical ventilation and <1% died.

CONCLUSIONS:

Infants accounted for over a fifth of children <18 years of age hospitalized for severe acute COVID-19, commonly manifesting with respiratory symptoms and complications. Although most infants hospitalized with COVID-19 did not suffer significant complications, longer term outcomes remain unclear. Notably, 75% of infants with severe disease were <6 months of age in this cohort study period, which predated maternal COVID-19 vaccination, underscoring the importance of maternal vaccination for COVID-19 in protecting the mother and infant.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Child, Hospitalized / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials / Risk factors Topics: Long Covid / Vaccines Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn / Pregnancy Country/Region as subject: North America Language: English Journal: Pediatr Infect Dis J Journal subject: Communicable Diseases / Pediatrics Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Child, Hospitalized / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials / Risk factors Topics: Long Covid / Vaccines Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn / Pregnancy Country/Region as subject: North America Language: English Journal: Pediatr Infect Dis J Journal subject: Communicable Diseases / Pediatrics Year: 2022 Document Type: Article