More Evidence of the Link of Interleukin-6 and Interleukin-10 with Critical COVID-19: A Report in Mexican Patients.
Iran J Immunol
; 18(4): 331-337, 2021 12.
Article
in English
| MEDLINE | ID: covidwho-1594484
ABSTRACT
BACKGROUND:
According to the World Health Organization, Mexico presents one of the highest mortality rates due to coronavirus disease 2019 (COVID-19). The "cytokine storm" phenomenon has been proposed as a pathological hallmark of severe COVID-19.OBJECTIVE:
To determine the association of serum cytokine levels with COVID-19 severity.METHODS:
We studied the cytokines IL-2, IL-4, IL-6, IL-10, TNF-α, and the IFN-γ serum levels through flow cytometry in 56 COVID-19 patients (24 critical and 32 non-critical) from Northwest Mexico.RESULTS:
We observed a significant increase in the IL-6 and the IL-10 levels in the sera of critical patients. These cytokines were also associated with mechanical ventilation necessity and death, IL-6 showing AUC values above 0.7 for both variables; and correlated with Na+, creatinine, and platelet levels. On the other hand, no association was found between IL-2, IL-4, TNF-α, and IFN-γ with tested variables.CONCLUSION:
Our results corroborate previous observations regarding IL-6 and IL-10 involvement in the severity of COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Interleukin-6
/
Interleukin-10
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Mexico
Language:
English
Journal:
Iran J Immunol
Year:
2021
Document Type:
Article
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