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Plasma S-Adenosylmethionine Is Associated with Lung Injury in COVID-19.
Kryukov, Evgeny Vladimirovich; Ivanov, Alexander Vladimirovich; Karpov, Vladimir Olegovich; Vasil'evich Aleksandrin, Valery; Dygai, Alexander Mikhaylovich; Kruglova, Maria Petrovna; Kostiuchenko, Gennady Ivanovich; Kazakov, Sergei Petrovich; Kubatiev, Aslan Amirkhanovich.
  • Kryukov EV; Burdenko Main Military Clinical Hospital, Ministry of Defense, Gospitalnaya Sq., 3, Moscow, 105229, Russia.
  • Ivanov AV; Institute of General Pathology and Pathophysiology, Baltiyskaya St., 8, Moscow, 125315, Russia.
  • Karpov VO; Burdenko Main Military Clinical Hospital, Ministry of Defense, Gospitalnaya Sq., 3, Moscow, 105229, Russia.
  • Vasil'evich Aleksandrin V; Institute of General Pathology and Pathophysiology, Baltiyskaya St., 8, Moscow, 125315, Russia.
  • Dygai AM; Institute of General Pathology and Pathophysiology, Baltiyskaya St., 8, Moscow, 125315, Russia.
  • Kruglova MP; Sechenov First Moscow State Medical University, Trubetskaya St., 8-2, Moscow, 119991, Russia.
  • Kostiuchenko GI; Regional Clinical Hospital, Lyapidevsky St., 1, Barnaul, 656024, Russia.
  • Kazakov SP; Burdenko Main Military Clinical Hospital, Ministry of Defense, Gospitalnaya Sq., 3, Moscow, 105229, Russia.
  • Kubatiev AA; Institute of General Pathology and Pathophysiology, Baltiyskaya St., 8, Moscow, 125315, Russia.
Dis Markers ; 2021: 7686374, 2021.
Article in English | MEDLINE | ID: covidwho-1595046
ABSTRACT

OBJECTIVE:

S-Adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) are indicators of global transmethylation and may play an important role as markers of severity of COVID-19.

METHODS:

The levels of plasma SAM and SAH were determined in patients admitted with COVID-19 (n = 56, mean age = 61). Lung injury was identified by computed tomography (CT) in accordance with the CT0-4 classification.

RESULTS:

SAM was found to be a potential marker of lung damage risk in COVID-19 patients (SAM > 80 nM; CT3,4 vs. CT 0-2 relative ratio (RR) was 3.0; p = 0.0029). SAM/SAH > 6.0 was also found to be a marker of lung injury (CT2-4 vs. CT0,1 RR = 3.47, p = 0.0004). There was a negative association between SAM and glutathione level (ρ = -0.343, p = 0.011). Interleukin-6 (IL-6) levels were associated with SAM (ρ = 0.44, p = 0.01) and SAH (ρ = 0.534, p = 0.001) levels.

CONCLUSIONS:

A high SAM level and high methylation index are associated with the risk of lung injury in patients with COVID-19. The association of SAM with IL-6 and glutathione indicates an important role of transmethylation in the development of cytokine imbalance and oxidative stress in patients with COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: S-Adenosylhomocysteine / S-Adenosylmethionine / Lung Injury / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Dis Markers Journal subject: Biochemistry Year: 2021 Document Type: Article Affiliation country: 2021

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Full text: Available Collection: International databases Database: MEDLINE Main subject: S-Adenosylhomocysteine / S-Adenosylmethionine / Lung Injury / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Dis Markers Journal subject: Biochemistry Year: 2021 Document Type: Article Affiliation country: 2021