Optically computed phase microscopy for quantitative dynamic imaging of label-free cells and nanoparticles.
Biomed Opt Express
; 13(1): 514-524, 2022 Jan 01.
Article
in English
| MEDLINE | ID: covidwho-1595429
ABSTRACT
Numerous drug delivery systems based on nanoparticles have been developed, such as those used in BioNTech/Pfizer's and Moderna's Covid vaccines. Knowledge on mechanical interactions between cells and nanoparticles is critical to advance the efficiency and safety of these drug delivery systems. To quantitatively track the motion of cell (transparent) and nanoparticles (nontransparent) with nanometer displacement sensitivity, we investigate a novel imaging technology, optically computed phase microscopy (OCPM) that processes 3D spatial-spectral data through optical computation. We demonstrate that OCPM has the capability to image the motion of cells and magnetic nanoparticles that are mechanically excited by an external magnetic field, quantitatively and in the en face plane.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Topics:
Vaccines
Language:
English
Journal:
Biomed Opt Express
Year:
2022
Document Type:
Article
Affiliation country:
BOE.449034
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