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Neutralizing Response Against SARS-CoV-2 Variants 8 Months After BNT162b2 Vaccination in Naive and COVID-19-Convalescent Individuals.
Luczkowiak, Joanna; Labiod, Nuria; Rivas, Gonzalo; Rolo, Marta; Lasala, Fátima; Lora-Tamayo, Jaime; Mancheno-Losa, Mikel; Rial-Crestelo, David; Pérez-Rivilla, Alfredo; Folgueira, María Dolores; Delgado, Rafael.
  • Luczkowiak J; Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.
  • Labiod N; Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.
  • Rivas G; Department of Microbiology, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Rolo M; Department of Microbiology, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Lasala F; Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.
  • Lora-Tamayo J; Department of Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Mancheno-Losa M; Department of Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Rial-Crestelo D; Department of Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Pérez-Rivilla A; Department of Microbiology, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Folgueira MD; School of Medicine, Universidad Complutense, Madrid, Spain.
  • Delgado R; Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.
J Infect Dis ; 225(11): 1905-1908, 2022 06 01.
Article in English | MEDLINE | ID: covidwho-1595523
ABSTRACT
We have investigated the evolution of the neutralizing response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants at 8 months after Pfizer-BNT162b2 vaccination in coronavirus disease 2019 (COVID-19)-naive (n = 21) and COVID-19-convalescent (n = 21) individuals. Neutralizing levels declined for all variants (range 2- to 3.7-fold). Eight months after vaccination, a significant proportion (4/21) of naive individuals lacked detectable neutralizing activity against the highly transmissible SARS-CoV-2 delta variant. In the convalescent group, the impressive high initial humoral response resulted in detectable neutralizing antibody levels against all variants throughout this period.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis