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A CLUSTER OF SARS-COV-2 DELTA VARIANT OF CONCERN ADDITIONALLY HARBORING F490S, NORTHERN LOMBARDY, ITALY.
Novazzi, Federica; Baj, Andreina; Pasciuta, Renee; Genoni, Angelo; Drago Ferrante, Francesca; Tripiciano, Rosalia; Catanoso, Giuseppe; Focosi, Daniele; Maggi, Fabrizio.
  • Novazzi F; Laboratory of Microbiology, ASST SetteLaghi, Varese, Italy.
  • Baj A; Laboratory of Microbiology, ASST SetteLaghi, Varese, Italy; Department of Medicine and Surgery, University of Insubria, Varese, Italy. Electronic address: andreina.baj@uninsubria.it.
  • Pasciuta R; Laboratory of Microbiology, ASST SetteLaghi, Varese, Italy.
  • Genoni A; Department of Medicine and Surgery, University of Insubria, Varese, Italy.
  • Drago Ferrante F; Laboratory of Microbiology, ASST SetteLaghi, Varese, Italy.
  • Tripiciano R; ATS Insubria, Varese, Italy.
  • Catanoso G; ATS Insubria, Varese, Italy.
  • Focosi D; North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy.
  • Maggi F; Laboratory of Microbiology, ASST SetteLaghi, Varese, Italy; Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Int J Infect Dis ; 116: 271-272, 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1596505
ABSTRACT
The Delta variant of concern (VOC) of SARS-CoV-2 has become dominant worldwide. In this article, we report a cluster caused by B.1.617.2 harboring the additional mutation of concern (MOC) F490S. We observed that 5 fully vaccinated subjects aged between 47 and 84 years were infected with this variant. The immune escape mutation F490S, first identified in the Lambda VOI, appears to impair vaccine efficacy and is rapidly increasing in prevalence worldwide.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study Topics: Vaccines / Variants Limits: Aged / Humans / Middle aged Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.ijid.2021.12.362

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study Topics: Vaccines / Variants Limits: Aged / Humans / Middle aged Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.ijid.2021.12.362