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Performance of a rapid antigen test for SARS-CoV-2 in Kenya.
Onsongo, Simon N; Otieno, Kephas; van Duijn, Shannen; Adams, Emily; Omollo, Mervis; Odero, Isdora A; K'Oloo, Alloys; Houben, Nathalie; Milimo, Emmanuel; Aroka, Robert; Barsosio, Hellen C; Oluoch, Fredrick; Odhiambo, Albert; Kariuki, Simon; de Wit, Tobias F Rinke.
  • Onsongo SN; Department of Pathology, Aga Khan Hospital, Kisumu, Kenya; Department of Pathology, Maseno University, Private Bag, Maseno, Kenya. Electronic address: simonya@live.com.
  • Otieno K; Malaria Branch, KEMRI/Centre for Global Health Research (CGHR), Kisumu, Kenya.
  • van Duijn S; Department Global Health University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands.
  • Adams E; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.
  • Omollo M; Malaria Branch, KEMRI/Centre for Global Health Research (CGHR), Kisumu, Kenya.
  • Odero IA; Malaria Branch, KEMRI/Centre for Global Health Research (CGHR), Kisumu, Kenya.
  • K'Oloo A; Malaria Branch, KEMRI/Centre for Global Health Research (CGHR), Kisumu, Kenya.
  • Houben N; Department of Research & Learning, Pharmaccess Foundation, Amsterdam, The Netherlands.
  • Milimo E; Department of Research & Learning, Pharmaccess Foundation, Amsterdam, The Netherlands.
  • Aroka R; Department of Research & Learning, Pharmaccess Foundation, Amsterdam, The Netherlands.
  • Barsosio HC; Malaria Branch, KEMRI/Centre for Global Health Research (CGHR), Kisumu, Kenya.
  • Oluoch F; Department of Health, Kisumu County, Kisumu, Kenya.
  • Odhiambo A; Department of Health, Kisumu County, Kisumu, Kenya.
  • Kariuki S; Malaria Branch, KEMRI/Centre for Global Health Research (CGHR), Kisumu, Kenya.
  • de Wit TFR; Department Global Health University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands; Department of Research & Learning, Pharmaccess Foundation, Amsterdam, The Netherlands.
Diagn Microbiol Infect Dis ; 102(2): 115591, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1596631
ABSTRACT
Testing for SARS-CoV-2 in resource-poor settings remains a considerable challenge. Gold standard nucleic acid tests are expensive and depend on availability of expensive equipment and highly trained laboratory staff. More affordable and easier rapid antigen tests are an attractive alternative. This study assessed field performance of such a test in western Kenya. We conducted a prospective multi-facility field evaluation study of NowCheck COVID-19 Ag-RDT compared to gold standard PCR. Two pairs of oropharyngeal and nasopharyngeal swabs were collected for comparative analysis. With 997 enrolled participants the Ag-RDT had a sensitivity 71.5% (63.2-78.6) and specificity of 97.5% (96.2-98.5) at cycle threshold value <40. Highest sensitivity of 87.7% (77.2-94.5) was observed in samples with cycle threshold values ≤30. NowCheck COVID-19 Ag-RDT performed well at multiple healthcare facilities in an African field setting. Operational specificity and sensitivity were close to WHO-recommended thresholds.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oropharynx / Nasopharynx / COVID-19 Serological Testing / SARS-CoV-2 / COVID-19 / Antigens, Viral Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Child / Female / Humans / Male / Middle aged Country/Region as subject: Africa Language: English Journal: Diagn Microbiol Infect Dis Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oropharynx / Nasopharynx / COVID-19 Serological Testing / SARS-CoV-2 / COVID-19 / Antigens, Viral Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Child / Female / Humans / Male / Middle aged Country/Region as subject: Africa Language: English Journal: Diagn Microbiol Infect Dis Year: 2022 Document Type: Article